Depression Fatigue Linked to Higher ATP Brain Energy Turnover
A 25-person pilot study of young adults found an ATP fatigue pattern that was directionally reversed from the simple “low brain energy” story: the depression group had higher visual-cortex ATP production metrics than healthy controls, while fatigue severity correlated with ATPase production rate, r = 0.73, p = 0.006.1 The cleaner interpretation is compensatory strain, …