NF1 Mouse Study Links Gut Microbiome to Brain Size and Autism-Like Traits
A 2026 NF1 mouse-model study found a gut-brain signal that was strongest in males: Nf1 +/- mice had altered gut microbiome composition, higher relative brain mass in 2 cohorts, reduced sociability, and combined autism-like phenotype shifts, with male microbiome beta diversity differing from controls at p = 0.0120.1 The result is a preclinical mechanism lead, …