Knee Osteoarthritis Pain and Fatigue Linked to Serum and CSF Metabolites
A 2026 targeted metabolomics study of knee osteoarthritis found 33 altered serum metabolites and 10 altered cerebrospinal-fluid metabolites, but the symptom signal split by compartment: serum amino acids, bile acids, and acylcarnitines tracked pain or fatigue, while CSF histamine and 3-hydroxyphenylacetic acid tracked central pain and sleep measures.1 Research Highlights 33 serum metabolites shifted: knee …