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Low-Level Lead Linked to Infant Neurodevelopment Through DNA Methylation

MHD featured image for low-level lead exposure, infant neurodevelopment, and FAM50B/PTCHD3 DNA methylation.

A 2026 prospective birth-cohort study in southern China linked mean cord-blood lead of 15.30 μg/L to lower infant neurodevelopmental scores across all 5 Ages and Stages Questionnaire domains, even though only 1.13% of samples exceeded 50 μg/L.1 A second finding was mechanistic: part of the lead-development association statistically ran through FAM50B/PTCHD3 DNA methylation, an epigenetic …

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