Antidepressants Did Not Shift Facial Emotion Recognition in Depression
A 2026 ANTLER mechanistic analysis found no evidence that maintaining antidepressants preserved a happier facial-emotion recognition pattern compared with placebo substitution at 12 weeks (adjusted mean difference 0.23, 95% CI −0.5 to 1.0, p = 0.5) or 52 weeks (0.29, 95% CI −0.5 to 1.2, p = 0.5). Research Highlights No 12-week maintenance advantage: discontinuation …