Adult ADHD Linked to Lower SIRT-1/Nrf-2/HO-1 Antioxidant Defenses
A 2026 case-control study found that treatment-naive adults with attention-deficit/hyperactivity disorder (ADHD) had much lower serum SIRT-1, Nrf-2, and HO-1 than matched controls, while TNF-α did not differ. The pattern points more toward impaired antioxidant-defense regulation than a simple broad-inflammation story. Research Highlights Antioxidant-defense markers were lower: adults with ADHD had lower SIRT-1 (9.36 vs. …