Astrocyte Calcium Signals Shape Amygdala Fear Memory and Extinction in Mice
A 2026 Nature mouse study found that basolateral amygdala astrocyte Ca2+ signals tracked fear retrieval and extinction, then showed causality: 3 mg/kg CNO manipulations of astrocyte DREADDs pushed early-extinction freezing in opposite directions while both disrupting later extinction retrieval.1 Research Highlights Astrocytes tracked fear state: after 3 tone-shock pairings and 2 days of 25 cue-only …