Cholestatic Liver Injury Alters Thalamus Fatigue Genes
A 2026 mouse study linked cholestatic liver injury to smaller thalamic volume than control injury-free mice, broad thalamus gene-expression changes, and partial pathway rescue after systemic tumor necrosis factor neutralization. Research Highlights Thalamic volume decreased: bile duct ligation (BDL; a mouse model of obstructive cholestatic liver injury) reduced thalamic volume vs. sham surgery by magnetic …