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Anti-CGRP Monoclonal Antibodies to Prevent Chronic Migraine (2023 Review)

Migraine, a primary headache disorder, significantly impacts the quality of life of millions worldwide. In recent years, the focus has shifted toward developing targeted therapies, particularly monoclonal antibodies (mAbs) against the calcitonin-gene-related peptide (CGRP), to prevent chronic migraine attacks. A relatively recent comprehensive network meta-analysis (NMA) evaluated the efficacy and safety of various anti-CGRP mAbs, …

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Does MSG Cause Headaches? Monosodium Glutamate Research Reviewed

Monosodium glutamate (MSG), commonly used as a flavor enhancer, has been controversially linked to headaches for decades. Key Facts: Human studies linking MSG to headaches have inconsistent findings, especially when MSG is consumed with food. Studies in which MSG reportedly causes headaches often have methodological flaws like inadequate blinding due to MSG’s strong taste. MSG …

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Botox For Migraines: Facial Injections To Prevent Headaches?

Botox (onabotulinumtoxinA) is a purified toxin derived from fermentation of the anaerobic bacterium Clostridium botulinum type A.  Most people are familiar with the cosmetic application of Botox whereby it is injected into facial muscles with the intent of reducing wrinkles, enhancing skin smoothness, and improving facial aesthetics. However, in addition to its cosmetic use, Botox …

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Zoloft (Sertraline) & Headaches: Does It Cause or Treat Headaches?

Zoloft (Sertraline), is an SSRI (selective serotonin reuptake inhibitor) prescribed for the treatment of major depressive disorder, OCD (obsessive-compulsive disorder), panic disorder, and social anxiety disorder.  It was approved by the FDA in 1991 and initially marketed by the pharmaceutical company Pfizer.  In 2013, Zoloft became the single most popular antidepressant medication in the United …

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Yoga For Migraines: A Non-Pharmacological Intervention

Migraines are characterized as intermittently-occurring, painful, throbbing headaches resulting from transient vasodilation of intracranial blood vessels.  Estimates suggest that for every 1 million persons in the general population, a total of 3000 migraine attacks will be experienced on a daily basis.  Although migraine is among the most common neurological disorders in both men and women, …

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Zomig (Zolmitriptan) Side Effects & Adverse Reactions (List)

Zomig (Zolmitriptan) is a medication marketed by AstraZeneca and is FDA-approved as an abortive therapy for migraines and cluster headaches.  Chemically, it’s classified as a triptan implying that it’s a tryptamine-derivative, and is manufactured in multiple formats including: tablet and nasal spray.  Similar to other triptans, Zomig is considered efficacious when administered during a migraine …

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