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Ketamine Increases Amygdala Volume in Treatment-Resistant Depression (TRD) (2024 MRI Study)

Depression is a complex mental health condition that significantly affects an individual’s emotional and physical well-being. Recent advances in neuroimaging have provided deeper insights into how major depressive disorder (MDD) alters brain structures, particularly the hippocampus and amygdala, and how treatments like ketamine can potentially reverse these changes. A new study using 3T and 7T …

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Nortriptyline-Induced “Room Tilt Illusion”: A Rare Adverse Event of Antidepressants (2024 Case Report)

Room Tilt Illusion (RTI) presents a perplexing challenge to both patients and physicians, transforming the familiar into the surreal as surroundings appear rotated or flipped. This rare condition, often linked to neurological or vestibular disorders, has recently been observed as an adverse effect of the antidepressant nortriptyline, used in treatment-resistant depression. A case report highlights …

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Effects of Stress & Negative Life Events on Brain Structure Connectivity in Adolescents (2024 Study)

Adolescence marks a pivotal era of transformation, where the brain undergoes significant development, shaping the trajectory of an individual’s emotional and psychological maturity. Recent studies, including one leveraging data from the IMAGEN Consortium, have evaluated how negative life events during these formative years can subtly yet significantly alter the structural connectivity of the adolescent brain. …

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Empagliflozin for Depression: Effective Adjunct with SSRIs (2024 Clinical Trial)

Major Depressive Disorder (MDD) impacts millions globally, making it a significant public health challenge. Traditional treatments like Selective Serotonin Reuptake Inhibitors (SSRIs) don’t work for everyone, highlighting the need for innovative approaches. Recent clinical trials exploring the use of empagliflozin, a medication originally used to lower blood sugar in diabetes patients, have shown promising results …

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Pharmaceutical & Recreational Drug Use During & After COVID-19 Pandemic (2020-2023 in Latvia) (2024 Study)

The COVID-19 pandemic has undeniably transformed various facets of human life, including our health behaviors and substance consumption patterns. Through the lens of wastewater-based epidemiology (WBE), a study conducted in Riga, Latvia, from December 2020 to July 2023, sheds light on how the pandemic and subsequent restrictions have impacted the use of pharmaceuticals and recreational …

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Myo-Inositol for Traumatic Brain Injury (TBI): Targeting BATF2 for Epigenetic & Transcriptomic Changes (2024 Study)

Traumatic brain injury (TBI) remains one of the most challenging conditions for modern neurology, carrying a wide range of long-term consequences that can significantly impair an individual’s quality of life. In a new study, researchers analyzed the epigenetic landscape post-TBI, revealing significant DNA methylation changes in the hippocampus—a crucial area for memory and learning. The …

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Melatonin Phases & Circadian Rhythms vs. Depression & Anhedonia Severity (2024 Study)

In the intricate world of mental health, the rhythms of our body’s natural processes play a pivotal role, particularly the circadian rhythm of melatonin, a hormone primarily produced by the pineal gland. Recent research suggests that variations in melatonin’s circadian rhythm might not only distinguish between depression and bipolar disorder but also correlate with the …

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