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Reset Modafinil Tolerance with Drug Holidays & Pitolisant-Bridging? (2023 Study)

Narcolepsy, a chronic neurological disorder, significantly impacts the daily lives of those affected due to excessive daytime sleepiness (EDS). Modafinil has been a cornerstone in managing EDS, but its effectiveness can wane over time due to tolerance. An innovative approach, using the drug pitolisant during modafinil ‘drug holidays’, offers new hope for resetting tolerance and …

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3 New Narcolepsy Medications (2015) In Clinical Trials

Narcolepsy is a neurological disorder associated with the brain’s inability to regulate sleep-wake cycles (and the circadian rhythm).  As a result, individuals diagnosed with narcolepsy often experience excessive daytime sleepiness and may fall asleep unexpectedly.  Some have suggested that the excessive daytime sleepiness stemming from narcolepsy is akin to how a normal person feels if …

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