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Cerebellum Activity Predicts Euthymia (Stable Mood) vs. Depression in Bipolar Disorder (2024 Study)

Bipolar disorder (BD), a complex and multifaceted mental illness, manifests through various mood states including depression, mania/hypomania, and euthymia. Recent advances in neuroimaging, particularly resting-state functional magnetic resonance imaging (fMRI), have shed light on the intricate dynamics of brain activity underlying these mood states. A new study employing dynamic fractional amplitude of low-frequency fluctuations (dfALFF) …

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Top 10 Repurposed Drug Candidates for Bipolar Disorder Uncovered via Gene Network Analysis (2024 Study)

Bipolar disorder (BD) remains a complex psychiatric condition with limited therapeutic options, posing a significant challenge in drug discovery. The latest research leverages network-based drug repurposing, employing advanced computational techniques to identify novel treatment strategies for bipolar disorder. Highlights: Network-based drug repurposing employs gene regulatory networks to identify potential new uses for existing drugs in …

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Serum Neurofilament Light (sNfL) as Biomarker for Bipolar Disorder? (2024 Study)

Bipolar Disorder (BD), a complex psychiatric condition, is under constant study to better understand its pathophysiology and improve diagnostic and treatment strategies. Recent research has focused on the role of serum neurofilament light (sNfL), a marker for neuro-axonal injury, in BD. Highlights: Individuals with BD for more than three years exhibit higher sNfL levels compared …

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Detecting Misdiagnosed Bipolar Disorder via MRI Brain Connectivity Analysis (2024 Study)

Bipolar Disorder (BD) and Major Depressive Disorder (MDD) are two of the most prevalent mood disorders, yet they are often misdiagnosed due to overlapping symptoms. This misdiagnosis can lead to inadequate treatment and worsened patient outcomes. However, recent advances in functional magnetic resonance imaging (fMRI) offer a promising solution to this challenge. By analyzing brain …

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Non-Invasive Brain Stimulation for Bipolar Disorder: Effective & Tolerable in Early Studies (2023)

Non-invasive brain stimulation (NIBS) presents a promising frontier for treating bipolar disorder, offering potential alternatives or adjuncts to conventional pharmacotherapy. Emerging evidence suggests that certain non-invasive brain stimulation protocols may help manage symptoms of bipolar disorder. Highlights: Efficacy: Certain NIBS modalities, like anodal tDCS over F3 plus cathodal tDCS over F4, have shown significant improvement …

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Antidepressants May Trigger Mania In Bipolar Disorder via Mitochondria

Antidepressants, commonly used to treat major depressive episodes in bipolar disorder, might have more profound effects on our body’s energy factories, the mitochondria, than previously understood. A recent study examined how certain antidepressants alter mitochondrial energetics, potentially influencing the risk of treatment-emergent mania in bipolar disorder patients. Highlights: Antidepressants Double Edged Sword: While crucial for …

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Adjunct Celecoxib for Depression & Mania: Treatment with a COX-2 Inhibitor

Celecoxib, a selective COX-2 inhibitor, shows promise as an effective and safe adjunct treatment for major depression and mania, according to a new comprehensive systematic review. The analysis also found celecoxib improved symptoms when used as a standalone antidepressant in patients with somatic disorders. However, evidence for efficacy in bipolar depression remains unclear. Key Facts: …

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