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Fish Oil Causing Depression or Anxiety? Consider Acetylcholine.

There is considerable evidence supporting the usage of fish oil for depression. The omega-3 fatty acids within fish oil are capable of increasing activity in the prefrontal cortex, enhancing neurotransmission, and reducing inflammation. Although they can be effective as a standalone treatment for mood disorders (e.g. depression), they are also commonly used with success as an augmentation strategy.

Despite the fact that many people have found fish oil (and omega-3s) to be tremendously beneficial for optimization of brain function, others have discovered that the fish oil exacerbates depression, anxiety, and brain fog. In the event that you are experiencing an increase in depression (or anxiety) from fish oil, there are some factors you’ll want to consider.

Factors to consider before blaming fish oil for worsening depression…

Things to consider before assuming that the fish oil is a direct culprit for the worsening of your condition include: the quality, the omega-3 content, other medications/supplements/drugs that you use, as well as individual factors (e.g. lifestyle, allergies, genetics).

1. Quality of fish oil

Taking low quality fish oil can have a toxic effect on both your brain functioning. You should always strive to take the best fish oil supplement on the market, rather than settling for low quality stuff that you’ll find at a local convenience store. The fish oil you take should be laboratory tested for toxins (PCBs, dioxins, Mercury, etc.), purity, and accuracy of ingredients.

You should never take fish oil that smells fishy as this indicates the possibility of rancidity. Fish oil should be stored out of the sunlight and in a cool environment (e.g. the fridge). If you haven’t properly stored your fish oil, are taking low quality stuff, and haven’t done your research, you are setting yourself up to feel worse. There’s no way to tell if you reacted badly to the “fish oil” or the fact that it was poor quality (e.g. rancid).

2. Omega-3 fatty acid content

Many fish oils contain varying amounts of omega-3 fatty acids (DHA and EPA). Some supplements contain slightly more EPA than DHA, while others are the opposite. Additionally some companies formulate fish oils that contain considerably more of one than the other, and others contain even ratios. Although many consider both DHA and EPA beneficial for brain health and mood, not everyone needs both.

Some people may find that DHA provides the most benefit, while others may conclude that EPA provides superior benefit. Certain formulations are available of 100% DHA and 100% EPA. Consider the amount of each of these omega-3s in your current supplement and realize that the ratio may be responsible for making your depression worse.

3. Other drugs, meds, supplements

If you are taking other drugs (e.g. marijuana, alcohol, etc.), pharmaceutical medications, and/or supplements while simultaneously taking fish oil, it’s difficult to specifically isolate the effect of fish oil. Always consider the fact that a worsening of depression (or anxiety) may be related to the side effects of the other substances that you’re using and/or an interaction that may have occurred between the particular substance and the fish oil.

Many people make the mistake of starting multiple supplements simultaneously, which makes it difficult to know whether: Supplement A or Supplement B is the actual culprit for feeling more depressed. If you’re taking fish oil as a standalone supplement, it will be much easier to conclude that the fish oil specifically worsened your condition rather than pinpointing blame on fish oil while taking a myriad of other substances.

4. Lifestyle

Consider any recent changes to your lifestyle that may have contributed to a worsening of your depression. While fish oil may be the direct culprit, if you recently took up any new activity that affects your brain, that could be the cause as well. For example, if you started taking fish oil and meditating on the same day, you won’t truly be able to determine whether the fish oil or the meditation worsened depression and anxiety.

Additionally if you are under significant stress from work, are dealing with a tough relationship, or going through a drug withdrawal, these are all things that may negatively affect your brain and physiology. Always think about what’s going on in your life before assuming a dietary supplement is to blame.

How Fish Oil May Worsen Depression or Anxiety

People love backing a supplement that has shown clinical promise in treating depression. That said, many of those same people fail to understand that not everyone has a good experience. It is important to realize that just because fish oil helps you doesn’t mean that it’ll help your friend, neighbor, or colleague.

Acetylcholine Theory

Perhaps the primary culprit for the worsening of your depression (or anxiety) as a result of fish oil supplementation is the neurotransmission of acetylcholine. Many researchers believe that supplementation of fish oil tends to increase extracellular levels of acetylcholine, a neurotransmitter involved in processing sensory information, recall memory, vigilance, and learning.

For individuals with abnormally low levels of acetylcholine, fish oil supplements will likely provide tremendous benefit. Chronically low levels of acetylcholine are associated with neurodegenerative diseases and cognitive deficits. However, among those who already have high levels of acetylcholine, (or in those who are sensitive to acetylcholine), fish oil may compound the existing problem.

Just a year ago, scientists discovered that when mice were given an SSRI, the drug increased levels of acetylcholinesterase (an enzyme that breaks down acetylcholine). By increasing acetylcholinesterase, you’ll lower levels of acetylcholine. The scientists speculated that although serotonin increase may help depression, reducing high acetylcholine may also be responsible for some of the antidepressant effect from an SSRI.

If fish oil is elevating your acetylcholine levels and acetylcholinesterase levels are low (or staying the same), you may end up feeling more anxious (and/or depressed) as a result of the supplementation.  Those who are sensitive to the effects of fish oil supplements may need to discontinue in hopes that acetylcholine levels naturally decrease.

  • Source: http://www.ncbi.nlm.nih.gov/pubmed/12221201

Amines: These are chemicals that are formed in food during the breakdown of amino acids. The most common of food-derived amines is that of histamine, which can cause a variety of unwanted psychiatric symptoms including depression and anxiety. Some people with a sensitivity to salicylate have reported that they aren’t able to tolerate fish oil capsules. It is speculated that they may have an unfavorable reaction to the amines.

Brain activity: It is possible that fish oil enhances homeostatic functioning and changes regional activity within the brain after consistent supplementation. This means your brain may literally re-wire itself in response to the supplement that it’s receiving. In many cases people notice that their cognitive function is enhanced and their mood improves.

However, for others the alteration of regional blood flow may be detrimental to mood and possibly cognitive performance. It should also be hypothesized that brain waves and QEEG patterns may change with continued fish oil supplementation. Although most evidence would suggest that fish oil is highly beneficial in promotion of healthy brain activity, supplement-induced changes may not be optimal for everyone.

Neurotransmitters: It is also important to consider that the fish oil may be affecting levels of other neurotransmitters that could increase levels of depression and/or anxiety. In addition to the aforementioned acetylcholine, other neurotransmitters affected by fish oil include: serotonin, dopamine, and glutamate. Increasing levels of omega-3s may enhance the efficiency by which neurotransmitters are delivered and may elevate levels. Some believe that levels of norepinephrine may be lowered after consistent omega-3 supplementation, but this claim is unverified.

What to do if fish oil makes you depressed…

It makes zero sense to continue supplementing something that makes you feel worse each day. Whenever conducting a supplement trial, you should document your mood and cognition (with some sort of test or chart) pre-trial, and then compare it at various timed checkpoints to determine whether you’ve improved or declined in mood and/or performance. Another couple options you could test include: reduce the dosage and frequency by which you supplement the fish oil, and you could also switch to a formulation with different omega-3 contents.

1. Discontinue

Common sense would suggest that you discontinue from the fish oil if it’s clearly making you feel worse. If may take awhile for you to bounce back to feeling normal after you’ve discontinued the supplement. While the fish oil isn’t going to have a major withdrawal like most antidepressants, your brain may take awhile to readjust to lowering levels of certain neurotransmitters (e.g. acetylcholine) that the fish oil was increasing.

2. Cut back

A second option to consider if you believe that you stand to benefit from omega-3 fatty acids is to simply reduce the dosage that you’re currently taking. High amounts of fish oil are more likely to elicit more significant changes within the brain. More significant changes are likely to occur when the dosage of the fish oil supplement is higher. However, not everyone needs a the same high, recommended dose.

Assuming your fish oil is of good quality, you may simply want to scale back on the quantity that you take. Some people are highly sensitive to the fish oil’s effects and may not need as much as others. In addition to cutting back on the dosage, you could also cut back on the frequency by which you take the fish oil. Instead of supplementing daily, supplement once every few days or with reduced frequency.

3. Alter omega-3 ratios

Some rodent studies suggest that increasing levels of DHA (an omega-3 in fish oil) may be responsible for increasing acetylcholine. If you suspect that the increase in acetylcholine is responsible for your increased depression and/or anxiety, it may be worth testing out a different formulation of fish oil that contains less DHA. There are some companies that make pure EPA (which may be what you’d want to try if you’re more concerned about mood than cognition).

Before jumping to conclusions as to which omega-3 fatty acid is causing the problem, you may want to test each one on for a trial and determine whether you react better to EPA, DHA, or a certain ratio of the two. This is something that most people don’t try, but may eliminate the problem.

  • Source: http://www.ncbi.nlm.nih.gov/pubmed/9408223

4. Consider L-Tyrosine

Although fish oil-induced depression hasn’t been thoroughly investigated in humans, if you buy into the theory that it may be a direct result of increased acetylcholine, you could possibly offset the effects by supplementing L-Tyrosine. In rodent studies, increasing levels of L-Tyrosine also increased acetylcholinesterase activity, thus helping break down more acetylcholine.

Assuming this has the same effect in humans, the L-Tyrosine would be increasing the amount of acetylcholinesterase, and you’d be lowering your acetylcholine. This may end up improving your mood assuming that it actually increases acetylcholinesterase in humans and that high acetylcholine was responsible for a worsening of your depression (or anxiety) while taking fish oil.

  • Source: http://www.ncbi.nlm.nih.gov/pubmed/23046746

5. Adjustment Phase

When you start taking any drug or supplement, there may be a phase during which your brain begins adapting to its effects. This is why it takes some people several weeks (or months) before they feel a noticeable difference after they start a supplement. It can take awhile for your brain to accommodate and adapt to the changes.

During the adaptation phase, some individuals may feel temporarily worse, before feeling better. This is a common experience among those who take antidepressants, but lesser reported among those taking supplements. Certain people may want to give fish oil a long trial before automatically assuming that the endgame will result in deep feelings of depression and/or anxiety. It may be worth continuing to supplement with the thought that the cumulative long-term outcome will outweigh short-term discomfort.

Have you experienced a worsening of depression from fish oil?

When any supplement is considered helpful for improving mood, you’ll find many people who have success using it. Then you’ll find some people who can’t really tell if it’s making a difference, and others that swear it’s making them worse. It is important to keep in mind that just because this is a supplement (as opposed to a pharmaceutical drug) does not make it void of potential side effects and adverse reactions.

Many people with high levels of acetylcholine may find that fish oil supplementation makes them feel increasingly depressed, anxious, or moody. Should you experience a “worsening” of your current condition, you probably shouldn’t keep taking fish oil. Just like not everyone responds well to certain drugs, not everyone responds well to certain supplements.

If you noticed that you’ve felt considerably worse from taking fish oil, feel free to share your experience in the comments section below. Be sure to mention how you know it was from the fish oil and not from any other supplements and/or lifestyle changes that you had made at the time. Share what symptoms you experienced, brand of fish oil, and the levels of omega-3s if you can remember – as this will help others get a more accurate understanding of your situation.

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{ 34 comments… add one }
  • James April 18, 2015, 7:53 pm

    You pose an interesting theory regarding Ach and adverse response. Another theory for the variation of the response with fish oil in the MDD population is perhaps based on inflammatory biomarkers as well as whether it’s EPA vs. DHA that’s being used.

    https://bbrfoundation.org/brain-matters-discoveries/omega-3-relieves-depression-symptoms-in-people-with-bodily-inflammation

  • Brit Bergesen June 3, 2015, 8:28 pm

    I had taken omega 3-6-9 blend flax seed oil for years, then I switched to fish oil and almost immediately had rapid heart rate, insomnia, night sweats, severe anxiety border panic attack, all of which I’d never had my entire life, EVER. I stopped taking the oil and symptoms began to slowly go away over the course of a week, then I began taking my flax seed omegas again and symptoms came back (but not as bad) so I stopped them as well. Could it be my body has just had enough?

    • GLOOM June 4, 2015, 9:47 pm

      Hmm… flax isn’t generally considered a very bioavailable source of omega-3s… it is poorly converted. Fish oil provides the body with a more potent kick of omega-3s. You could have purchased oxidized, rancid, or low quality fish oil.

      Or you could just react poorly to the fish oil (e.g. allergic reaction). If you think something’s wrong, always consult a medical professional. That said, a good rule of thumb is to avoid over-supplementation.

      You may want to take a break from any supplemental omegas for several months. The concept or hormesis would suggest that it’s best to cycle on and off of various supplements rather than take them daily. And finally, always listen to your body.

      If a substance is giving you these symptoms, stop taking it for awhile and reassess your situation. Best of luck.

      • Kay June 30, 2015, 4:38 pm

        Hi I just came across this and am happy I did. 4 years ago I took Evening Primrose Oil supplements and came down with a terrible bout of anxiety and depression when I had previously never experienced it before. I quit it and after a few horrible months it tapered off. I have found myself ever since then very sensitive, in that I guess once the path (anxiety and depression) has been made, it is much easier to find yourself on it again. Anyways, the past few weeks I have been fighting to not travel down that dark path again. I just awoke this morning and realized that I just started supplementing with flaxseed oil a couple of months ago. I am going to stop. This article has been a fantastic help.

  • Kyle August 12, 2015, 5:13 am

    You, I believe, are spot on.

    I found this site while searching about the effects of choline after noticing that all of the following made my symptoms much more pronounced: ALCAR, Fish Oil, Alpha GPC, and also eating a large quantity of eggs.

    I am going to try Tyrosine and see if it helps with acetylcholinesterase. I appreciate you making this post, it has really helped me confirm my speculation about this.

  • Jen October 22, 2015, 8:21 pm

    About 2 months ago I started doing Crossfit & I decided to become a CF-L1, during our lecture they mentioned taking fish oil because its an anti inflammatory (your muscles get inflamed after a hard workout.) So this part Saturday I was in a CF competition so I thought it would be a great day to start taking my fish oil supplements. Boy, was I WRONG, talk about anxiety, depression and mood swings! Its Thursday and I’ve been in some kind of funk since Sunday.

    I’ve tired listening to music, crafting, the normal feel good things for me and I have not been able to knock it. So my boyfriend asks what wrong with me, I’m like I don’t know what the hell is going on, the only thing I’ve done differently is take fish oil. BINGGGGG, I Google fish oil and depression and it’s everywhere that if you have high levels of acetylcholine then you can have these effects. would have been nice to know before hand, but I’d much rather have inflamed muscles and be happy.

  • Heddy November 27, 2015, 5:34 pm

    I have become very sensitive to omega 3. Even from drinking organic milk. I am well into menopause. But when consuming even small amounts of omega 3 in food, my endometriosis flares up and I get very hormonal.

  • KJB December 25, 2015, 7:40 am

    Marvelously written. Good things to consider.

  • sicily January 6, 2016, 10:53 pm

    In menopause depression and anxiety severe and I heard that omega-3 can help depression. I’ve taken it two different times and each made me more depressed and anxious. I’m anxious and crying off and on… I’ve not sure if I should take vitamin D then. Anybody know the difference?

  • Tim February 11, 2016, 10:38 am

    Great article. I have been trying various supplements to help with anxiety, depression and depersonalization disorder. One of them was a fairly high quality fish oil pill, but it didn’t seem to help. It’s hard to tell though because I was taking some other supplements as well. I do eat a lot of eggs, and I noticed one person commented that eating a lot of eggs sets his symptoms off worse. Anyone else had this experience? I just wanna get back to feeling like me again! Thanks.

  • Laurie February 28, 2016, 7:36 pm

    I started taking Evening Primrose oil capsules in hopes of improving hair, and after 3 days noticed feeling EXTREMELY depressed. Stop taking and returned to normal. Starting putting about 1/4 cup of ground flax seed on cereal and in about 3 days starting feeling EXTREMELY depressed. Stopped and returned to normal. Started taking fish oil supplements and same thing. Felt EXTREMELY depressed, quit and returned to normal.

    These supplementation occurred months apart, and I repeated the experiment with them even years apart with the same results. Interestingly, the “feel” of the depression had a particular depression signature. So, the only commonality I guessed was Omega 3, and that my body processed it differently than most. It’s frustrating because I want to know why. I have genetically high cholesterol and would love to understand what’s going on.

    • Emma September 9, 2016, 9:35 am

      Oh my god this is exactly me! I just told the same story to my husband! I was trying these 3 at 3 separate times for PMS. Bad results every time with all 3 tried at separate times! This week was when I tried flaxseeds every day and I have become depressed and my anxiety is Back, I then realized hang on a minute I was the same when I took EPO or fish oil then found this on Google! So what do we do?

  • Adrian March 12, 2016, 6:04 am

    I’m pretty sure I have general anxiety but overall its pretty manageable I still am able to function in life. I came across this thread because the last 2 days I’ve felt overwhelming anxiety to the point where I feel I’m going to have a nervous breakdown. 3 days ago I started taking Fish oil supplement with 750 mg EPA and 250 DHA.

    Specifically took fish oil in hopes of helping out my mood. The last 2 days my anxiety has increased tremendously and I feel depressed, hard to sleep at night I kept waking up. I can’t prove 100% its fish oil but its a pretty big coincidence. Just wanted to share my experience.

  • Susan Strand March 21, 2016, 4:06 pm

    62, athletic, healthy, and small, I have self diagnosed myself as having a negative reaction (nighttime talking head syndrome, moodiness) by taking fish oils of quality, Puritan Pride (Triple Omega 3-6-9), and low dose 1 instead of 3, and a combo blend, or just fish oil. Have experimented over the past few months, and yep, it’s the fish oil! My family does have history of allergies, of all sorts, cross reactions, so I’m not surprised when any
    supplement may cause a reaction. Bottom line, thank you for this article. It gives credence to my own trials and experiments!

  • Angie April 21, 2016, 4:17 am

    I have already been diagnosed that I have an acetylcholine dominance thus taking antidepressants. I was in a great way and was told to take fish oil. I took 2-5 capsules a day because I heard in an online lecture that high levels (750-1500 mg) omega-3, particularly DHA, is the equivalent to a dose of antidepressant.

    Well, I’m in a bad way… Still. I quit fish oil a week ago but I’m such a mess. How long until I’ll get better? I can hardly function some days. I’m so glad I came across this article though. Thank you.

  • Jennifer April 28, 2016, 8:22 pm

    I am so glad I found this article. With EVERYTHING touting omegas as a help for depression, it has taken me a long time to realize that my spikes in depression have coincided with taking omegas – and I mean very high grade omegas. This is a relief.

    • Victor M Hogue May 25, 2016, 12:24 am

      Soap Box Time… 63, Health Nut since I’ve been alive. Flax Seed Omega user for years. No adverse reactions ever. Started consistent New Chapter Wild Alaskan Salmon, 1 bottle then 2… then switched to the Hawaiian BIO ASTIN (ASTAXANTHIN) WOW! This took me down hard and for a long time. Quit Cold Turkey… and still had horrible feelings, light headed, mood swings, the blues for months.

      I only made it through by continuing my life long diet and work out regimen. I would freak out at night, where I would have an anxious feeling coming on, and would hit the door for a power walk. Way too much energy… and this went on for ever…months. Always at night. I finally made it through the fogginess… and today I finally had a good day and feel I’m coming back.

      A nutritionist I collaborate with, told me, since I was type “O” Blood, I can’t handle DHA OR EPA…or anything going straight to my brain. It begins to rewire it. After ETS’D from the Army, I was put on Paxil, Zoloft and others, NOPE! Couldn’t handle it. Some people just can supplement their brains. Now, I just eat fish once or twice a week. I find one needs to be careful when supplementing anything.

      Remember, everything on this living planet need the basics: Sunshine, Water, Stimulation (exercise) Nutrition from good whole food. My feel good pill, work out everyday….and if you engage in a Weight Lifting, it will boost your testosterone… really… without a doubt. Watermelon too. I hate when it’ s not in season. Mushy… Men, I promise, if you eat a bowl full every night, WOW.

      Good Feelings, Good Mood… and Frisky. Then you can rinse your mouth with Warm Water because of the Sugar. Also, massage your testicles for about 1 minute. Really. Remember Stop the Sugar and Whole Grains….it will fire you up all the time… and is simply not good for some people. i.e. If I’m going to take a ride on my horse for 3 days, I usually dry-stall him and feed him lots of good high protein grain, this way he’ll be ready to go and endure the ride.

      Horses can only eat certain kinds of grain and Hay, but Cows can eat pretty much any kind. The Acid in Sudan is not good for horses. Point being, Whole Grains can cause problems in humans too. I.e. upon staying fit, my blood pressure was a little elevated, and I was easily agitated. I ate whole grain and sugar as if it was free, as long as I would keep eating it.

      I got off, lost 10 lbs of useless fat, and it changed my life. Blood pressure dropped to normal levels, even though it was never really extremely high. Remember my Message to the Brain MTTB… when you’re about to drink that Coke, or eat that Candy Bar, “It’s only as good, as long, as it goes over your tongue” That’s it… if you tell yourself that over and over… you will wean yourself off sweets.

      My thoughts on supplementing; Sometimes you can over think your condition, and over supplement. Your bodies receptors may not absorb or process each supplement you take, and some supplements may be blocking others, which in turn will be a waste of time and money. Go back to basics. When you were younger, you could eat anything, because your burned it off in an hour. Now that you’re older, fuel yourself accordingly.

      Formula for Life: Sunshine (at least 1-20 mins per day on as much of your body as possible) Fresh Water (A lot) Nutrition, always include protein, and Exercise… Sweat everyday (body’s exhaust system). Prayer and Socialization… If you’re having withdrawals from a brain supplement, drink lots of water, use a dry sauna to sweat, eat lots of fruits and veggies and keep exercising. It will pass quicker than if you don’t.

      “Exercise is free and you’ll never run out of supply.” Thank you. I’ll be here all week… Vic

  • Jjg May 11, 2016, 5:12 am

    Everything people have been reporting: anxiety insomnia, increased depression, and I will add extreme agitation, and waking up in a panic, were things I experienced after two diff types of HIGH quality fish oil after about 2 weeks of each. Same thing with flaxseed oil. I take lexapro which helps, and reading your blog about how SSRIs decrease acetylcholine… now it makes sense why this happened.

    Now I am afraid to touch anything with omega 3 in it. One thing not mentioned here is DMAE which apparently is found in high amounts in fish oil, which may be why it’s doubly devastating, compared to flaxseed oil, at least in my experience.

  • Toulouse June 2, 2016, 5:35 pm

    I have been dealing with anxiety for the last 3 months, starting with a few panic attacks. They went away, but still had general anxiety, but was controlling it with CBT and doing well. Two days ago I started taking Fish Oil Omega 3 supplements and coincidentally I have a flare up in anxiety the last two days – back to the high level, near panic.

    I’ve taken Omega 3 on and off, sometimes a few days in a row, then not doing it for a month, so the use has been very sporadic. But now I’m wondering if my earlier panic bouts had anything to do with the Omegas. I’ll not be taking them and see how it goes.

  • Simon June 4, 2016, 12:34 am

    Thank you for this article. I have tried high quality, mixed DHA/EPA supplements four times over the last three years. I keep a diary and I have noticed a distinct worsening of depression on them every time. I was drawn back (not any more) to fish oil by all of the benefits for inflammation in the scientific literature.

    In addition to increasing acetylcholine, fish oil also lowers my (already low) BP and hypotension for me, induces a delayed increase in epinephrine, which makes me feel worse. I have similar problems on hypotension with niacin, magnesium, olive leaf oil. Does anyone know if acetylcholine reduces dopamine?

  • Treece June 14, 2016, 5:31 pm

    I have noticed that both fish oil and eggs make my depression get more so. Since fish oil is “supposed” to help depression lesson, I always thought I was making the whole thing up – I didn’t believe myself. I would keep going back to using it because it was “supposed” to help. Even though it didn’t.

    Recently I was prescribed estriol cream at a low dose and it really ended up that I became worse depressed. This time I stopped using the cream. I believed my Self. Everyone has their own individual biochemical composition; not one of us is a statistic. Try new things in small amounts, and listen for your own body’s symphony. :)

  • Pär June 15, 2016, 12:59 pm

    I think a big problem is that fish oil becomes rancid when it get’s in the body. It’s very important to take a stable fish oil like Eskimo Pure 3. I got all side effects by high concentrated fish oil. Heart palpitations, anxiety, etc. – but not by a natural stable unconcentrated fish oil. I am not selling anything.

  • Chase June 28, 2016, 4:15 pm

    Hey, I came here in my search for answers as I’ve been suffering from anxiety for the past few months. After restricting food items, caffeine, nicotine, I finally decided to cut by my supplements one by one. Not much change. Then the last one, the one I least expected. After three days of stopping Fish Oil supplementation my anxiety was completely gone.

    It felt like all the static adrenaline had vacated my body, my mind was clear, I could sleep again, I drank coffee without issue, it felt like I had awoken from a dream. To test this I went back on 2x 1200mg Fish Oil caps first thing in the morning and within a few days started to spiral again. I have since stopped supplementing Fish Oil.

    It’s been two days since that test and I already feel the anxious tension and brain fog lifting. We’re all wired differently I guess.

  • Karen July 4, 2016, 4:55 pm

    Started taking omega 3 caps at recommendation of optometrist for dry eyes. Also hoped it would decrease joint pain. Am a chronic depression sufferer successfully treated with paxil. Insomnia started within a few weeks of starting omega 3 caps as well as night sweats and agitation. Didn’t make the connection and doubled omega 3 dose and increased paxil to reduce insomnia.

    Increased paxil helped insomnia for a while but soon sleeping problems resumed. Finally realized problem might be omega 3s. Quit cold turkey and now sleeping better but still waking up with brain fog and anxiety after four days of stopping. Hoping it clears soon. Glad I read this and am not alone because believed omega 3 supplementation could only be beneficial. Not for me! Will also watch flaxseed now…

  • Julie August 7, 2016, 8:30 am

    I started taking it and developed horrible insomnia and agitation.

  • Donna Helinski August 26, 2016, 4:36 pm

    After taking high amount of Omegavia 500EPA while taking Celexa (SSRI) – My kid had increased anxiety, depression began then Processing &Sensory & Hyperaware and increased to crisis level. Stopped all meds/supplements and began steroid to calm and now a bit better.

    Do you know how long it takes the Acetylcholine level to correct and will it? Afraid of permanent damage. I cited your webpage to hospital and outpatient PANDAS Doc so they won’t blame PANDAS for this new occurrence that I believe is from the fish oil and celexa combo.

  • Janet August 31, 2016, 3:48 am

    Thank you for such a clearly written article. I bought some Bioglan 2000mg fish oil capsules to treat osteoarthritis. The dosage for “joint health” on the container is 4 capsules per day, a much larger dose than I’ve ever taken in the past. I have had night sweats, restless legs at night which I usually only get on very hot nights (it’s winter now where I am), twitchy legs during the day, extreme anxiety and very low mood, extreme irritability, persistent agitation, couldn’t focus on anything, felt deaf as though I were hearing things through ear plugs, etc. I put two and two together by the fourth day (yesterday) and today I feel back to normal. What a nightmare!

  • Bentley August 31, 2016, 8:28 am

    I have suffered from anxiety and panic attacks for years. My experience has been the opposite. I am on an SSRI and I have noticed that when I exercise and take fish oil things get better. Specifically, it seems to help the effectiveness of the SSRI. Since every post on this site has contained a negative experience between fish oil and cognitive symptoms I hesitated to post this but having dealt with this for years and trying this all very systematically I am confident that fish oil HAS helped me.

  • mike September 11, 2016, 10:57 pm

    I was taking a high DHA supplement 800+ and found it caused high anxiety and rapid heart beat/panic attacks…

  • Valerie September 26, 2016, 8:05 pm

    I purchased Nature Made Omega 3 fish oil 1400 MG and took just one pill an hour before bedtime. Within that hour I experienced a faster heart rate, racing thoughts, body aches, dizziness and a bad headache. I immediately returned the bottle for a full refund the next day.

    This was 6 days ago and I’m still feeling the anxiety. I was coming out of a depression also with some anxiety. I read online that omega 3 fish oil helps with both anxiety and depression but that definitely was not the case for me.

  • PalmettoMoon October 16, 2016, 6:25 pm

    Just a suggestion. I’m on 40mg of viibryd and would not want to come off of it. Doc said take fish oil for my high cholesterol. I did. Not good. So, I researched and found that a good high quality Hemp oil is a lot better for Omega 3’s than any fish oil. It comes in gel cap form just like fish oil. Might work for some and not for others. Depression needs to be researched as much as cancer has non profit organizations. Its a much larger epidemic than cancer and it’s not talked about as much because people in general think depression is a thing that’s just “all in your head”. Total misconception!

  • Rachel November 14, 2016, 10:25 pm

    I hope to help others by my experience. I believe myself to have a depressive predisposition. I have the MTHFR A1298c homo variation (23 and me tested). And a couple other detox hindrance markers. Anyways….

    I had a baby and reverted back to my depressive worst (that started when I was 16. I am now 41 and have worked VERY hard with diet, exercise, social connections and supplements to get to a good place). But all my coping mechanisms weren’t helping and because I was breastfeeding, I had to do everything au natural. What got me out of the hormonal tailspin was l-tyrosine.

    But I have just discovered and the fish oil may have been exacerbating my symptoms. I have been taking fish oil for 10+ years thinking it was supposed to help. My closest Whole Foods ran out of my normal Nordic Naturals DHA so I bought an EPA heavy one. I was suicidal! I didn’t put the connection together until I started sharing the supplement with my husband who is very even keeled. When he got suicidal too – we both stopped immediately.

    Fish oil can be very dangerous for your mental health. Trust your feelings! And maybe try the tyrosine instead. Take 500-1000mg first thing in the morning when you open your eyes. Wait an hour to eat anything. It also helps with muscle recovery and tiredness. Lord knows – with my second baby, it helped me survive the newborn phase with a smile on my face :)

    • alex December 2, 2016, 12:00 am

      Hi Rachel. I was just wondering if you went back to the DHA Nordic naturals? I take this one too and have never had problems until I started taking two. I did this for about two weeks (before had only been taking one in the morning) and began to have anxiety/insomnia issues. I then went back to one for about a week but eventually just stopped altogether.

      I have been off them for about 10 days now. Things are better and I would like to start back at just one a day due to the beneficial effects of the omega 3s… I don’t feel like I really get enough at all through plant base foods and I don’t really want to eat fish for fear of mercury, etc… I felt good for years on this supplement and just wonder if that increase in dose messed me up and I could start back now since I took a 10 day break. I would only take one and would maybe not even take it everyday.

  • Katy November 20, 2016, 9:58 am

    Wow, this has been amazing to discover this page. Such helpful suggestions. I’ve been recently tapering my Sertraline/Zoloft with the aim to come off after about 5 yrs on them. I’ve overhauled my diet over the last six months and have been feeling fantastic (low carb, high fat, moderate protein = ⬇️30 lbs so far).

    Anyway, I reduced my Sertraline from 100 to 50 per day over a month with no discernible decline in mood and then last week I started taking good quality fish oil for the DHA… Well. My depression has reared up with a vengeance! Even thinking I’d be better off dead etc, etc. Which I haven’t contemplated in a looong time (Zoloft worked very well for me).

    Anyway, after coming across this page, it’s jogged my memory that perhaps Ive come across this reaction before with Evening Primrose Oil and even fish oil at other times… Glad to know there’s a bio-chemical reaction going on. I’m going to look further into l-tyrosine and I will cease the fish oil for now…

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