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Wellbutrin (Bupropion) Withdrawal Symptoms: How Long Do They Last?

Wellbutrin (Bupropion) is a drug that is used for the treatment of depression as well as to help people quit smoking. It has become a very popular medication to treat depression because it is considered to have a minimal side effect profile compared to many other drugs. Wellbutrin is not associated with weight gain, a loss of sex drive, and loss of energy like many other antidepressants. It works as a norepinephrine-dopamine reuptake inhibitor (NDRI) as opposed to most conventional antidepressants which target serotonin.

It has become a popular off-label treatment option for chronic fatigue, sexual dysfunction, and weight loss. It is also considered a popular antidepressant augmentation strategy when used in conjunction with an SSRI. The only major side effect associated with this drug is an increase in risk of having a seizure. The medication also operates as a nicotonic receptor agonist – which explains why it helps people quit smoking. In some cases, it is even used for the treatment of attention-deficit hyperactivity disorder (read more: Wellbutrin for ADHD).

Since this drug has such a low side effect profile compared to many other medications, many people try it first before SSRI’s. Although this drug has been used by many people, not everyone has a positive reaction to the drug. Others that are on it for awhile may want to come off of it and experience life naturally without the influence of an antidepressant. If you plan on withdrawing, it is important to be aware of the potential symptoms that you may experience.

Factors that influence Wellbutrin withdrawal include

As with any drug, there are various factors that are thought to influence the withdrawal process. The amount of time that you took the drug, the dosage that you took, your individual physiology, and whether you tapered all can influence the time it takes for you to recover back to “normal.”

1. Time Span

How long were you taking Wellbutrin? If you were only on it for a few weeks, you may be able to quit cold turkey without any major withdrawal symptoms. On the other hand, if you were on this drug for over a year or many years, the withdrawal process will likely be more difficult. Generally the longer you are on this medication, the more gradually you should taper off of it to minimize with withdrawal effects.

2. Dosage (100 mg, 150 mg, 300 mg) + Subtype (IR, SR, XL)

The dose that you took of Wellbutrin can be significant when it comes to withdrawal. If you were on the highest possible dose, you are going to need to conduct a gradual taper to avoid most withdrawal effects. Besides the dose, you also need to recognize that there are a few different subtypes of this medication:

  • Wellbutrin IR (Immediate Release)
  • Wellbutrin SR (Sustained Release)
  • Wellbutrin XL (Extended Release)

The “IR” version stands for “immediate release” – these tend to be shorter acting than the other two subtypes. The “SR” version is “sustained release” and typically is taken twice throughout the day, while the “XL” version is “extended release” and only taken once a day. It is generally going to be easier to come off of the SR version because you can simply reduce the pills.

3. Cold turkey vs. Tapering

It is always recommended to conduct a gradual taper off of Wellbutrin to minimize withdrawal symptoms. Most people conduct a gradual taper by reducing their dosage 25 mg to 50 mg every 2 weeks. If you are on the XL version, the pill only comes in doses of 150 mg and 300 mg. Since you cannot simply “cut” the extended release version, you may want to switch over to the IR (immediate-release) to conduct a proper taper. If you notice a significant amount of withdrawal symptoms, taper at a slower rate.

Unless you have been taking Wellbutrin for a very short period of time, it is never recommended to quit “cold turkey.” Many people have simply quit “cold turkey” without any major side effects – including myself, but many people have experienced exacerbated withdrawals because they did not taper. It’s usually best to err on the side of caution and gradually wean yourself off of Wellbutrin.

4. Individual Physiology

It is important to point out that everyone reacts differently to these medications. Your nervous system, your environment, and your social support will all play a role in helping you through withdrawal. Believe it or not, there are people out there who barely even notice when they stop taking Wellbutrin because they exhibit “zero withdrawal” symptoms.

Yet there are other people who haven’t even taken the medication for a long term period and they exhibit very difficult withdrawal symptoms. Understand that everyone is different and you can’t really compare your journey through withdrawal with that of another person.

Wellbutrin Withdrawal Symptoms

Since everyone has a unique experience in regards to drug withdrawal, symptoms are subject to variation. Some people may experience anxiety and lethargy, while others may experience crying spells and body aches. You may experience everything on this list, a few symptoms, or nothing at all. This is just a collective of symptoms that have been reported during withdrawal from Wellbutrin.

  • Anger: Many people experience anger and sometimes “rage” when they quit taking this medication. I remember when I stopped taking it I felt pretty angry and more impulsive than I usually do. If you have become crabby within the first week of stopping this drug, it is likely a result of the withdrawal.
  • Anxiety: Some people become pretty anxious when they stop taking Wellbutrin. In most cases while on this medication, anxiety tends to increase. However, some people also experience an increase when coming off of it. Although an anxious response upon withdrawal may seem counterintuitive, it’s very possible.
  • Body aches: It is pretty common to experience general muscle aches and pains throughout the body when coming off of Wellbutrin. These may be uncomfortable for a few days, but will eventually subside. If they are difficult to deal with, make sure you are getting plenty of rest, water, and consider taking some over-the-counter pain relief.
  • Crying spells: You may want to cry all day when you first stop taking this medication. This is because your emotions are running rampant and your depression may have come back full force. In fact the depression that you experience during withdrawal may be even more severe than before you started the drug. Realize that the crying is normal to experience during withdrawal.
  • Depersonalization: While taking this drug you may feel “depersonalized” or unlike yourself. When you stop taking it, you may continue to experience this symptom. It will eventually go away. If you panic about feeling this way, it may continue to make it worse.
  • Depression: Many people feel good on the Wellbutrin and when they quit taking it, their depression rears its ugly head again. Realize that withdrawal from any medication is going to result in depression – usually pretty severe. This is because your neurotransmitter levels have not stabilized. Some people mistakenly think their depression is “worse” after the medication when really it’s a result of a chemical imbalance caused by withdrawal.
  • Dizziness: Nearly all antidepressant withdrawals are associated with feelings of dizziness. If you feel dizzy when coming off of this drug, you are not alone. Most people experience some sort of dizziness and in some cases vertigo as a result of their withdrawal. This is just a sign that your body was expecting the drug and it is no longer receiving it so it reacts by making you dizzy.
  • Fatigue: Since this medication has a stimulating effect and tends to give people a lot of energy, it is common to experience fatigue, lethargy, and sleepiness when someone quits this drug. For most people, the fatigue will subside within a few weeks. This is because this drug was inhibiting dopamine reuptake and norepinephrine – now you no longer have that going on.
  • Headaches: During withdrawal, many people report feeling headaches – some to the point of migraines. If you are struggling with a withdrawal headache, the best thing you can do for yourself is rest, drink plenty of water, and relax.
  • Increased appetite: Being on this medication tends to make people have less of an appetite.  When they quit taking it, their appetite returns to normal and they eat more.  This is associated with a weight gain that people experience when they quit Bupropion.
  • Insomnia: Although most people experience insomnia while on Wellbutrin, it is also possible to experience it while coming off of the drug. During any withdrawal, your body and brain are trying to restore normal function without the drug. Therefore you may have difficulty falling asleep at night.
  • Irritability: Many people become irritable when they come off of an antidepressant. Wellbutrin tends to do a great job at making people feel less depressed and more energetic. When you take away the antidepressant effect and reduce a person’s energy, they may become irritable.
  • Lack of coordination: During the withdrawal period, your coordination may become “off” and you may have difficulties performing tasks. Not everyone experiences this, but if you notice that your coordination seems off, you may want to stay away from heavy machinery and/or driving until it returns.
  • Libido changes: Some people report that their libido decreases during withdrawal from Wellbutrin. This is due to the fact that while they were on the medication, it actually increased their sex drive – in some cases to the point of “hypersexuality.” When quitting this medication, you may notice a temporary drop in sexual interest.
  • Nausea: Many people report feeling nauseated when they quit taking Wellbutrin. This goes hand-in-hand with vomiting that people experience. The nausea may become so extreme that it causes a person to throw up. This symptom may last for awhile before you feel less nauseated.
  • Seizures: One tricky symptom that needs to be highlighted is that of seizures. If you are susceptible to seizures, you should have never taken this medication in the first place. Anyways some people end up taking this medication for awhile, withdraw too quickly and experience seizures. Although these aren’t common, they do happen which is why you should always withdraw gradually with caution.
  • Vomiting: It has been reported that some people end up vomiting during their withdrawal process. This is simply a natural reaction to the body trying to respond to no longer having the drug for functioning.
  • Weight gain: Wellbutrin is an antidepressant that causes weight loss in many people that take it. It does this by speeding up the body’s natural metabolic response while simultaneously decreasing appetite. It has a stimulating effect for most people which also promotes activity. When people quit, their metabolism returns to a baseline, their full appetite returns, and they may become lethargic – a recipe for weight gain.

Note: It is understood that Wellbutrin stays in your system for days after your last dose.  The bupropion itself is eliminated usually within 5 days, but its active metabolites can take up to 10 days for elimination.  For this reason, discontinuation symptoms may become most noticeable after being drug-free for 5-10 days.

How long does Wellbutrin withdrawal last?

For most people, the withdrawal symptoms will depend on how long they took Wellbutrin and how quickly they tapered off of it. It can be difficult for someone who has been on this medication for years to come off of it without experiencing significant withdrawal symptoms. For other individuals the withdrawal process is very minimal and may last just a few days before the majority of symptoms subside. It is common to report withdrawal symptoms lasting up to 8 full weeks following their last dose of Wellbutrin.

Some individuals have experienced symptoms that persist for up to 90 days (3 months) following their last dose of this drug – this is evidence that everyone recovers at a different pace. I personally have been on this medication and for me it was among the easiest antidepressants to withdraw from. Although for me there were withdrawal symptoms, they were nothing compared to my experience quitting Paxil cold turkey and withdrawal from other SSRI’s. Keep in mind that everyone is different and may experience different reactions.

One person that has been on the drug for years and decides to quit may exhibit discontinuation symptoms for months following their last dose of Wellbutrin. In order to speed up the withdrawal process and eradicate any symptoms you are experiencing, it is recommended to engage in healthy activities that promote recovery. Make sure you are getting plenty of exercise, eating a healthy diet, and getting outside for some sunlight. Do your best to socialize with friends and family, and stay as productive as you can. For most individuals, they will return to normal mental functioning within a couple of weeks.

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{ 164 comments… add one }
  • Jim T. May 4, 2014, 10:39 pm

    I cold turkeyed WB a week and half a go, and have gained 7 punts in that time. I exercise regularly, and am relatively careful about what I eat, so there should be no reason that I am gaining this weight. I have however noticed that wild cravings have returned, and I decided today that I’m going back on the med. I have a feeling I’ll be on it for teh rest of my life.

    • GLOOM May 5, 2014, 5:48 am

      Hey Jim, the reason is likely due to discontinuation of the WB… Likely nothing you can control. Your bodyweight will stabilize over time if you stay off of the medication. Many people take it to lose weight as it speeds up the metabolism. Best of luck.

      • Peggy Ham October 20, 2016, 3:48 pm

        I found WB made me gain weight – 30 lbs in 2 months – I also had headaches, constipation, body aches, sweating, limb weakness, stomach pain – I cannot wait for it to get out of my system.

  • BrijaH June 27, 2014, 4:23 am

    I quit cold turkey about 3 weeks ago now off of WB 100mg for depression. I only had taken it only for about 6 months, but now coming off I have zero apetite, nausea that lasts ALL day, and real bad headaches. This is my 8th day feeling this way and im so over it. Because it was half a year with WB im hoping I wont be feeling so terrible for that much longer? its tortourous. :(

    • Daniel August 9, 2014, 6:02 pm

      The reason why you are, or were feeling that way is because you went off cold turkey rather than tapering off your dosage. Even though 100mg is a fairly low dosage, you were on it for 6 months. That’s more than enough time to warrant a taper because the drug has already plenty of time to make the changes to your brain chemistry. Going cold turkey put your brain into shock. It’s been used to having a certain balance of neurotransmitters, then once you abruptly ceased the medication your brain notices the imbalance and lack of neurotransmitters and is trying regain balance and normal levels. I’m surprised that you said you’ve been off for three weeks, but have noticed those side effects for only eight days. The withdrawal symptoms should’ve been apparent just about a day or two after you stopped cold turkey. Either way, you should feel better within a few weeks once your brain’s neurotransmitters stabilize and the brain re learns how to function without the presence of bupropion. If you haven’t felt better by this time..I notice you posted in June, you may consider going back on bupropion, wait until you stabilize and then start a taper. You’d be surprised how even a two-three week taper can diminish many, if not all of the symptoms. Good luck

      • Dan December 5, 2014, 1:23 pm

        Hello Daniel, You seem knowledgeable…I took Wellbutrin XL 150mg for 6 & 1/2 weeks, and stopped 4 days ago. I’ve actually felt better since stopping it, other than some periods of agitation, and couldn’t sleep last night. Do you think my withdrawal will last much longer, given the short duration that I took the medication (and a fairly low dose)?

  • Helena July 1, 2014, 4:39 pm

    I was taking 300mg XL for years and just decided to stop cold turkey about a month and a half ago. I am just now starting to really feel the side effects so this is how I cam to find this page. I’m hoping that 1 more month of this is all it takes to stop feeling all the symptoms.

    • Shirley April 15, 2016, 11:58 pm

      Helena – Can you tell me how you are feeling now? I have been on wellbutrin for over 10 years and wanted to get off. I have weaned myself off and it has been 4 weeks. I feel like crap. I am so lethargic and tired. Just feel lousy. I am going to give it 2 more weeks and than I’m thinking of going to doctor for some blood work. Want to make sure something else isn’t wrong with me.

      • Dianne June 14, 2016, 7:20 pm

        I’m also taking XL 300mg, I would like to reduce the dose to 150. I’ve been taking the two different doses every other day, so I can adjust to the lower dose. I’ve felt so tired. Was wondering if this was normal.

        • Sarah June 17, 2016, 2:17 am

          I had reduced down to 150 XL four weeks ago. It has been a bit of a rollercoaster ride. Some days high as a kite, and other days I don’t want to get out of bed. Plus the headaches have been a pain. I was told this is normal, your body adjusting to the lower dose. I have one 150XL left and I was thinking of cold turkeying it after that one. I have been on this drug for 6 years. Maybe I will go get some IR’s and taper down again. I hope that helps.

  • Nikki B July 11, 2014, 9:53 pm

    I been on WB SR for 6 months and I started at 150mg 2x a day then went to 200mg a day. So now I’m down to 100mg for the pass two months and I’m weening myself off with my dr. And I’m taking one 100mg a day and this is my 2nd day and I’m not feel to good. I am feeling not myself like depolarization. We I first start taking WB about 2 months in I was feeling this way an they put me on kloinpin 0.5. So now that I’m coming off of it it’s starting to happen again even while on kloinpin. So I want to know is if anyone felt this before and how long will this last. Please so one help!!!

    • DJ October 3, 2014, 9:58 pm

      Like me you may not be want to come off of it. I don’t want to take meds but just a fact of life for some of us. I take lamictal also though, you could ask your Dr about that, its a mood stabilizer. Sounds like maybe that could help. I dont know. Just idea :). I never hesitated to guess and test with my doc.

    • Andrea s February 12, 2016, 3:59 pm

      I too after about 1 & 1 /2 to 2 months found that it wasn’t working for me. It was great in the beginning and then stopped even with increased dosing. Yet still with the side effects. I’m weaning down. With me SSRIs make me feel terrible as well. I may be resistant to antidepressants.

  • Jane August 25, 2014, 4:59 pm

    I quit cold turkey about two weeks ago, and I’m also trying to quit smoking as my husband and I are trying for our first child. I’ve been feeling awful, especially with the dizziness and confusion. I’m just wondering if it’s recommended to quit both at once, or if I should let the wellbutrin symptoms subside before quitting smoking. It’s very important to me that I quit both soon. Thanks!

    • Ian June 6, 2015, 3:39 pm

      Let the smoking withdrawal subside, then quit Wellbutrin!

      • Michael September 6, 2016, 9:41 pm

        I agree with Ian. The smoking is worse for the baby.

  • Cher September 23, 2014, 9:36 pm

    I was cut from 150mg twice a day to 100mg twice a day because I’m trying to wean myself off of this. When I was taking 150, I missed one dose and the next day I could not get out of bed. How long should I stay at 100mg twice a day and how should I progress? I’ve been taking Wellbutrin since April 2014. I’m hoping the side effects are minimal. I have lost 80lbs recently and do not want to gain. Are there any natural remedies that might help counteract the side effects? I currently practice daily yoga and meditation. Thank you!

  • Kathryn September 23, 2014, 11:49 pm

    I stopped taking the Bupropion 150 HCL X (generic for XL) almost a week ago. I started the RX , the beginning of Feb. 2014. Generally I feel just about the same as I did before Bupropion was prescribed. However I do feel more off-balance then usual and my tinnitus (which I’ve had way before the prescription and increased with the prescription) hasn’t calmed down at all.

    To be frank, I was physically off-balance before I took the prescription and while taking it, that sensation was lessened; now it’s back to pre prescription. I’m off balance because of falling accident back in 2011. My PA prescribed it for depression and truthfully it didn’t help all that much. I was and am still anxious. It did however numb a bit and also helped with appetite depressant. Now I’m wondering if I should or shouldn’t get back on Bupropion. I would like to find a more natural route.

  • Frank September 26, 2014, 2:34 pm

    I’d been on 300 Mg Wellbutrin SR for 1-1/2 years. Over a month ago I cut that to 150 Mg with no noticeable effects. 3 days ago I stopped the 150 Mg cold turkey, primarily because I felt it increase insomnia for me ever since I started on it 1-1/2 years ago. A bout of diarrhea the 1st couple days and the 2nd day, for whatever reason, couldn’t force myself out of bed until 11;30 a.m. Just felt lazy; not sick, not depressed…just lazy. Today, the 3rd day I said enough of that and got up at the usual 7:00 a.m. No withdrawal symptoms to complain of, but time will tell. I’ve told myself if I start feeling the least bit depressed I’m going back on.

    • James October 13, 2015, 6:41 am

      Frank, I have also been taking 300XL for 1 & 1/2 years and I am seriously considering quitting the same method you described- cut it down to 150 and then cold turkey. I am curious, how are you now? Did you notice any more symptoms? Did you go back on it?

      • Jacky November 27, 2016, 6:27 pm

        James, Not sure how long you wrote this but I’m currently cutting down from 300 xl to 150 and after that I want to quit cold turkey. How did it go for you? I’ve been on 150 for the last 5 days and have had headaches and crying spells.

  • Norma Miller September 27, 2014, 2:46 am

    I had to get off my meds pretty much cold turkey due to a financial situation which was not my desire at all. However, the reasons for going on the meds in the first place-a son manifesting classic signs of autism, a negative, hurtful marriage situation have remedied themselves, and i have experienced a lot of emotional healing, so i felt ok with it as did my husband. I am at about week 4 since my last pill. I am struggling, but i am determined to stick it out. My main issues are chronic fatigue and dizziness.

    I had that issue at week 2, but then thought it was over, but it has returned with a vengeance along with joint pain and achiness. I am hopeful it is almost over. I am very worried about weight gain because i am seriously overweight and recently gained more. It hurts my body and i am concerned about my health. I feel good about this decision, though, because i felt like my brain was foggy and my husband says my mind seems much more clear now. Something a friend told me that may help is that amino acid deficiency can cause many symptoms that cause people to take anti depressants and can alleviate the withdrawals. I did discover i am deficient in those, so i want to buy some.

  • Emily October 20, 2014, 10:00 am

    thanks for this article it really helped, I’ve been on the medication for 6 weeks and i’ve stopped cold turkey (I really just forgot to take them for a week while I was moving). Insomnia is the only side effect that I’m really having but I had that while on the medication. How long do you think the withdrawal process will go since I was on it for a very short period of time. I didn’t notice a change in my depression while on it just high uncomfortable energy which is why I have stopped taking it.

    • Dan December 5, 2014, 1:21 pm

      Hello Emily, You are describing my situation exactly. I tool the WB XL 150mg for 6 1/2 weeks, and stopped 4 days ago. I had insomnia before, but had slept well (with medication help) until last night (so at 3 & 1/2 days after last dose). I’m just wondering how the rest of your withdrawal process went. Please share. I didn’t think that 150mg for 6 weeks would require a taper?!

      • MARLENE November 7, 2015, 5:37 am

        I’ve taken 150xl for about 2 months. Being able to stay awake allday was the best. The agitation has progressively gotten worse. I asked Dr. to take me off. I took 1/2 pill 2 days and then none. It has been a week. I cry all the time. I am mad much of the time. I am throwing things, breaking things, uncontrollable crying and some screaming. I am scaring myself. Can’t reach Doc because of weekend. Wonder about ER. Thinking they would not get involved with these meds… HELP.

        • Anne'liese January 11, 2016, 9:04 am

          Dear Marlene… reading your experiences really makes me think that you should taper your decrease rather than quit cold turkey. I have been on 150mg XL for just under a year and am quitting cold turkey myself. I initially tapered for a week or so but Christmas got in the way of monitoring this. I am having very vivid dreams but most importantly, have stopped with the ‘flushing’ problem.

          I can also sleep better through the night now. I am going through menopause and the flushing was becoming intolerable. I can now wear more clothes as opposed to next to nothing! Body aches are a big problem and I have experienced anger and crying spells. I do have a medical background and should have known better and tapered, but the flushing was just too intolerable.

          Again, I suggest tapering. Has anyone else experienced somewhat crippling body aches? Muscle relaxants help somewhat as well as minimal alcohol, as it itself is a muscle relaxant. Good luck.

          • Peggy Ham October 20, 2016, 4:01 pm

            I had horrible sweats and vivid dreams, constipation, crippling body aches, an incredible “out in space” feeling. I could hardly get out of bed in the morning. I had my dosage upped from 150 mg xl to 450xl and that is when the trouble started and with no improvement to my health. I have now stopped cold turkey – day 2 and not much different than before quitting.

      • LW January 12, 2016, 5:52 am

        I tried to quit cold turkey after being on Wellbutrin for years. I woke up one night to having strike like symptoms. My left side went numb and I could not speak properly. It took a good 20 minutes to come to. Then a year later, I accidentally stopped taking Wellbutrin, misunderstanding my doctor’s instructions and had the same type of situation. Although my left side did not go numb, I went into a panic thinking it was going to happen again. It was an awful feeling. Now I’m concerned I will never be able to get off of Wellbutrin because I’m terrified of the feeling I experienced before! Suggestions?!?

        • Sue January 30, 2016, 1:34 am

          I hope your symptoms have tapered off. A doctor put me on 150 mg, then quickly increased to 300 mg thinking I was depressed. The truth is, I was nutritionally deficient, anemic, low on Vit D3, and B12. Fast forward several years, I am remarried, relocated and my current doctor wants me off the Wellbutrin. I finally have agreed. Since moving, I have also stated taking Folic Acid and Magnesium.

          I have been concerned about the warning label that says “May cause drowsiness.” I am always tired! My doctor has sketched out a plan that will have me completely off in 4 weeks. If I feel unsettled, I will discuss with her at my next appointment. I would not suggest quitting any prescribed medication cold turkey without discussing with a doctor.

      • Randi September 24, 2016, 5:16 am

        I was put on a low dose of the generic Wellbutrin (bupropion SR) and took it for about 6.5 weeks as well. While I took it, it made me feel terrible. Angry, irritable and crazy. The doctor said it should be fine that I just stop cold turkey because it being a low dose & I wasn’t on it for long… But I feel that was a HUGE mistake. Now my depression is horrible.

        I feel disconnected from the world around me & get awful thoughts o.s. (abbreviated for trigger censoring). It is so scary. Now my doc is putting me on other meds, which scares me; I’m afraid I’ll get into a never ending cycle of things that won’t work. How long did the anxious / depression withdrawal symptoms last for any of you? Did you get put on meds to help quite the thoughts/ ease the edge?

    • Laura April 18, 2015, 1:21 am

      Yes, I have not had my wellbutrin now for 5 days because I forgot to take it. I worked the night shift and just plain forgot. I realized it tonight and began to look up the withdrawal symptoms. Lo and behold DIZZINESS and HEADACHE. Felt like crap basically. I actually think I was getting over the yucky feeling this evening. However I took it tonight. Anxious to see how I feel in the morning. (Taking 150 mg XL once a day, since last September).

  • BeaC October 21, 2014, 6:23 am

    Worst withdrawal for me. I wasn’t even on it for long. The rage was unlike any anger I have felt before and it was constant. I am back on it as well as Ritalin and within a few days I am great. I feel like a normal, level headed individual. I was taking Zyban originally for smoking cessation and Ritalin for ADHD and we just discovered that I was a much happier person.

    I became careless and kept forgetting to fill my prescription, didn’t really understand how big of a deal that was and was inconsistent with it and that’s when the extended withdrawal began. I know better now for the future. The combo has worked for both my ADHD and my depression so yay for me!

  • Ruby October 23, 2014, 6:14 pm

    I have been taking Wellbutrin 150 SR for 15 years. September 4,2014 I refilled my prescription and noticed a significant change in the pill color (now faded purple and barely and odor) they don’t smell like sulfur as the other pill did. Within a week of taken my new prescription I developed severe panic attacks, severe insomnia, 8 lbs weight loss, (keep in mind I was only 108 lbs 5’2″ to begin with) cry at the drop of a hat, hypnotic jerking trying to rest or fall asleep, sweating profusely, diarrhea, rage, muscle pain, difficulty concentrating, extreme sensitivity to noise, heart racing and the list goes on.

    Nothing has changed in my life but something is definitely wrong. I made the pharmacy aware of my findings and they have been doing some research for me. I have come to discover that a new company bought the rights to this drug. I am told they can not change the drug itself, however they can change the non medicinal ingredients. I am wondering what the heck they have done with this pill. I wound up in emergency twice in three weeks only to be given Clonazepam and Lorazepam to help with anxiety. Are these people for real.

    I have great respect for doctors and their gifts but, people, we are being bombarded with these anti-depressants and anti anxiety pills to the point where 1/2 the world is taking them. My pharmacy gave me 30 of the generic brand of bupropion SR 150 to try but I have yet to take one. There needs to be mandatory brain testing done before people should be given any mood altering drug and from what I hear there is a test now available in Canada. My hope is to come off these pills. That’s my story. Thanks.

    • Adrienne February 22, 2015, 2:25 pm

      Ruby, I too had been on Wellbutrin XL for 12 plus years, on my retirement with lessen my expenses I went to Bupropion which is the generic for Wellbutrin XL and absolutely felt no change what so ever, I’ve been nearly 4 years retired and this is the only antidepressant I take, compared to previously being on 3 for the same number of years. I don’t think I would fear trying the Bupropion at least for a short period of time to see if it helps, for me if this is the only medicine I have to take for the rest of my life along with Klonopin for my panic and anxiety it is well worth it as I live a feel energetic life and feel great.

      The other withdrawals from let’s say Paxil and others were horrendous disasters for me and I never want to experience that again. I did try for months to taper off Bupropion and my body just would not adjust without it so I am happy to report that being a survivor of CFS and many of the other related illnesses and disease of depression and anorexia that all go hand in hand, I will be on a couple of med’s for life and glad they are available to treat my symptoms so I can live a normal life~ Good Luck and I do hope you find what works best for you, just be sure you have a good support system along with your doctors to help you make the decisions you need for YOU.

    • Meg March 7, 2016, 4:39 pm

      I totally agree that there are way too many people on these drugs today. It’s a cop-out to prescribe an otherwise healthy human with chemicals for isolated events like divorce, stress, etc. I was on citalopram for 5 long (somewhat awful in the grand scheme of my life) years. My doc prescribed wellbutrin when I started feeling like crap this past Sept.

      I cried a lot, ended up quitting a good job and now I’m living through the aftermath of that decision. I don’t regret quitting the citalopram so if quitting a good job was a necessary result then I’m fine with that. Six months later and I’ve decided to taper off wellbu. So far I’m feeling the fatigue and am experiencing the feeling of being “not myself.” I’m hoping this ends soon.

      I was on 150mg and three weeks ago I started taking 100. When that 30 pill bottle runs out, I’m thinking I just won’t refill. I want and need to be drug-free. My doc says I should stay on an anti-depressant but although I went through a few episodes in my twenties, I would rather live a life without these poisons in my blood than get relief for those episodes. Too many of us take meds!!

      • Kathi August 18, 2016, 4:04 am

        I started taking Wellbutrin 150 XL for depression for 1 week and increased to 300 XL, I have taken it for 7.5 months. I have noticed that I have gotten impulsive, rude, heat aches, tremors, sweating lost 50 lbs. I have asked my doctor to wean me off of them. The process is 150 XL for 14 days after that one pill every other day for 7 days. I was told no withdrawals because of the weaning process. Today is day 2, I’m sure to early to notice anything, but will keep you posted.

        • Jacky November 27, 2016, 6:35 pm

          Hi Kathi, I’m thinking of tapering off Wellbutrin XL 150 with the schedule you recommended. How did it go for you? Any suggestions? I was on 300 for over a year and I’m currently on 150 for the last week.

  • David November 12, 2014, 1:36 am

    I don’t know how you all can do this, but congrats if you can… My story: I’ve been on Wellbutrin since 1998 and have wanted to get off of it for years twice I slowly lower doses (or forgot to take them) until off completely only to find myself to the point of not wanting to leave the house or go anywhere, only to ramp back up until I was just OK again, my doctor at the time said “you’re probably going to have to be on it the rest of your life.” I’d sure like to find an alternative but know of nothing better at the time until something else or some better understanding comes along.

    • Helen July 29, 2015, 10:16 pm

      I have been told that L-Tyrosine could be helpful. Just check with your Doctor before you make any changes. I did read a book called The MoodCure by Julia Ross, that gave some in-depth information on how this can be accomplished. Help this helps.

      • Ellen August 24, 2015, 6:16 pm

        I read that book too, it’s wonderful. It really helped me get well. Maybe I should give it another read. Going on off WB is a struggle. I am going to give it a week and see how I feel. I feel like I am checked out, could just sit and stare into space for hours and sleep!!

    • Tara October 19, 2015, 3:54 pm

      I’ve been weaning myself off Wellbutrin and at first I felt severe depression, rage, anger, so I went right back on. On my second attempt to get off it, I used 5-htp, a natural mood enhancer that actually works. I’m down to a quarter of a wellbutrin pill and I feel great. The only problem is the weight gain. I HATE it. I’m trying to find out more info as to how much I can expect to gain. How long will the weight gain last? Anyway, back to the 5-HTP. Buy only Natrol brand (the others made me nauseaus). The take the 200 mg time release in the morning. Works like magic!

  • Uncle Bob November 17, 2014, 2:05 pm

    I have been on the lowest dosage for 6 years or so and came off of it around 6 weeks ago. I have been getting a few headaches here and there. The only major side effect for me is my lack of blood flow and its effect on my libido/sex life. I am in “dumb jock mode” right now being VERY concerned about this. It is affecting my mood which is counter productive to going off of WB!

  • Peggy December 7, 2014, 10:43 pm

    1st I just want to say I’m very disturbed about the things I’m learning as I go through this process. I’m on many different meds right now & hope to at least minimize if not completely get off of unnecessary use. I’ve been on meds for 30 yrs. Somehow through all the major brain fog from heavy meds that kept me disabled where I could not even be aware of what was happening with me, I saw a light.

    5 weeks ago my Dr, per my request agreed to decrease my bupropion, and with no discussion of any withdrawal symptoms or gameplan took me from 400 mg to 300 mg a day. The 1st week was the worst, and it slowly got better. Now today, 5 weeks later I’m going through painful withdrawal & a bad headache that I pray doesn’t become a migraine. Crying spells come & go, never lasting more than an hour. I want off all my meds, but don’t know if too much damage has been done. Considering I can actually write coherently, let alone speak clearly is a good sign.

    I have learned never, never, never just take Any kind of med because your Dr thinks it’s the best decision for you. That’s a decision at the very least should be talked about together concerning side effects & long term use. Find other options 1st that are safer & weigh out pros & cons for each. For me personally, if I can treat something with Holistic Medicine that is not only better for you, but also healthy for you, that’s what I’m going to do. I wish everyone the best.

  • Julia December 12, 2014, 6:28 pm

    I was diagnosed with major depressive disorder and anxiety disorder when I was 14 years old. I used to take Zoloft but I didn’t like the side effects so my doctor switched me to bupropion. I was taking 150mg of bupropion for about a year and then quit cold turkey (this was about four months ago) and my anxiety increased tremendously. I was having panic attacks on a daily basis and felt slightly nauseous.

    Just recently (one month ago) I was put back on it for my depression/anxiety but this time I was put on 300mg. It’s been helping with my panic attacks and anxiety but I still feel depressed at times. The reason why I’m writing on here is because I forgot to take my medication for two days (I used to take it before bed but it caused major insomnia so I switched to the morning, which is probably why I forgot) and now I feel horrible.

    I am very nauseous and dizzy and I have a pounding migraine. I’m not sure if these are considered withdrawal symptoms, being that my body reacted so quickly, but by reading this article, that seems to be the case. I took it first thing this morning and will continue to do so. Hopefully these symptoms will go away with the next couple days.

    • V January 31, 2016, 4:20 pm

      I took the generic brand of Wellnutrin for one day. I had dizziness and a migraine that day. 26 hours later, and after deciding not to take a second pill, I am too dizzy to drive or leave the house. I also feel nauseous and a bit out of myself. One day may seem too short, but the fact that you experienced withdrawal after two days makes me think this medicine actually is that impactful.

  • Alice January 8, 2015, 6:24 pm

    I was on Bupropion 300 XL for a couple of years. I tried to taper myself off slowly as it was making me irritable and giving me uncontrollable anxiety. I started to experience generalized numbness and twitching after cutting down. It scared me so I started taking it full time again. Symptoms did not go away so I went into the clinic. Was told symptoms likely due to the bupropion so to start coming off of it again.

    Me being the genius that I am I quit cold turkey and went completely mental, crying, depression, still twitching and numbness. At this point I was pretty sure I had some horrible disease. Anyway went in AGAIN and they told me to start taking them again, slowly, so I did. Starting experiencing really horrible unrelenting body aches and continued twitching. The aches were bad enough that I couldn’t sleep or concentrate on anything else. Went in AGAIN. Told anxiety was likely the problem.

    They were not sure what the aches were coming from but to discontinue the wellbutrin. So I have been off of it for 4 days now. Body aches went away for a couple of days immediately but are back now with the twitching and numbness, severe depression and anxiety. I am a pretty big mess in other words. It’s horrible. I have convinced myself that I have a disease but all of the medical professionals I have talked to think my symptoms are likely due to the bupropion and anxiety. Any similar experiences? I just want to be back to my normal self. Never messing with this medication again.

    • Dora April 24, 2016, 7:53 pm

      Did your outcome end up well? And how long did it take for the withdrawal side effects to stop?

    • Jamie August 23, 2016, 2:18 pm

      Hi Alice… I read your post and it hit “home” with me… I have been on 150MG Bupropion and 20MG Lexapro for MANY years due to a terrible divorce. As its been 4 years since the divorce, my life is great, work good, and I’ve recently found the love of my life I decided “it’s time to get off these drugs”.

      With that said, I decided like an idiot to stop “cold turkey” and am experiencing TERRIBLE itching!!! Did you by chance have this symptom?? I am most positive this is a side effect as nothing else has changed on my life. I am going to try now and ‘wean’ myself off now, as i cant live with this itching!!!! Just wondering if you experienced this.

      • Jeanne September 29, 2016, 4:01 am

        I discontinued 2 weeks ago after 10 years (150xl). I have been crying for 4 days now. I had the realization earlier that I was mad about everything and irritable and the itching started yesterday. I will resume tomorrow until I have a taper plan. Worst part, it leaves me with no energy.

  • David January 26, 2015, 10:11 am

    I’m so thankful for this site! I thought it was a case of sinusitis or other minor crap that I’ve been going through that kept me up at night. And that the lack of sleep was making me irritable. I’d taken Wellbutrin XR for about 5 years, peaking at 450 mg. So I guess I should have expected this. It would have been nice if my new psychiatrist had warned me about these.

    FWIW, my new doc says that the standard of care with these meds is to reach an effective dose and then discontinue after 18 months. If there’s a relapse, try another 18 months and then withdraw again. If there’s another relapse, then chronic use may be considered. Also, for those under 18 years old, it’s 12 months but the same cycle. Again, thanks so much for this info! (And why can’t medical pros just lay it out?)

  • Naht Myan February 1, 2015, 2:43 am

    I have been using 100mg to 150 mg Wellbutrin daily for a decade. During the time is works I lose weight that needs to go, stop biting my fingernails, and don’t smoke or drink. I have to go cold turkey for two months every year as the Wellbutrin slowly wears off and then stops working completely. Increasing the dosage only results in nerves not a “fix”. I gain weight, smoke, and get fat, depersonalized, suffer classic flu like drug withdrawal and feel as if I lose 20 point of IQ.

    The withdrawal can be confusing due to Wellbutrin having several metabolites all psychoactive to one degree or another and having wildly different half lives from 24 hours to 2 weeks. After the initial drug withdrawal issues you need time for your brain to even be able to produce the same level of neurotransmitters you were producing before taking the W. Good luck because you may feel nothing at first and then slowly slide into various side effects over days to several weeks and it may not seem related to the W. due to the length of time before the symptoms maximize.

    I give it ten weeks and then start the 100mg a day to reach a stable level over about three weeks (those weird half lives again). For me the results are so good that I am willing to suffer for ten weeks a year to get 40 weeks feeling great.

  • Dee February 5, 2015, 1:41 am

    I was taking Wellbutrin 300 mg XL for four years. At the beginning of January, I had a grand mal seizure (something that has never happened before). I was in the hospital for 3 days and after many tests, they felt the Wellbutrin was the issue and they took me off of it cold turkey. I saw my Dr. 5 days later and he didn’t seem very concerned about it…the first two weeks, I actually felt better than I had when I took it.

    But since then, I feel terrible, I’m not myself, I cry all of the time, I feel such doom, such sadness. I have an appointment with another Dr. in two days, so I’m hopeful they can bring some relief or give me information to help me understand how terrible I feel. Any information you can share with me would be greatly appreciated. Thanks.

    • Theresa Vaughn February 27, 2015, 12:11 pm

      I have felt your pain having these symptoms in the past going off lamictal. I felt like I was losing my mind, dreadful. I take paxil for depression and anxiety and the Wb 300mg XL to quit smoking. Today is my first day for cutting back from 300 to 150. I will see how things go for a week or so. I’m hoping that by taking the paxil it will buffer any side effects that might be caused from backing off the Wb. It never gave me energy. I wish you the best of luck and take care :)

    • Kim March 16, 2015, 2:09 am

      Hi, I’m curious how you are doing? My experience is similar to yours. On 300 mg XL for a couple of years. About three months ago I started having panic attacks. After two months of dealing with panic and anxiety my doctor suggested I stop taking the WB. I cut down to 150 mg for a week and then quit cold turkey. The first few days I felt really down, but then started feeling great, and by the second week thought I was going to be fine without anything.

      Unfortunately, last week, after two weeks and 3 days being off of them I hit bottom and felt completely hopeless. I had gone to see a herbalist about the time I went off Wellbutrin. I’m on many herbal supplements including Omega 3s, B complex, B12, D, probiotic, amino acids, and magnesium. Also eastern supplements Ashwaganda and Free and Easy Wanderer for the past two weeks. I started on SAMe a week ago for the depression. The SAMe definitely helped. I’m taking 400 mg a day. I feel better, but still not great, or back to normal. I’m hoping to be able to go the natural route and not go back on prescription meds.

  • Robin February 10, 2015, 3:54 am

    I can testify that even taking for a short time and stopping is bad. I have only been in WB 300mg XL (for depression) for a month and my doctor did not give me a refill…I did not know this so I ran completely out before realizing this. I went without for 3 days and had horrible withdrawals. Headaches, nausea, racing thoughts all night, and confusion. My pharmacist loaned me 4 pills until my doctor calls more in. This makes me scared to keep taking it, but I am much worse without it.

  • Trisha February 20, 2015, 4:24 am

    I have been on Wellbutrin 150mg XL for about 15 months along with 20mg of Cipralex that I take once a day and have for a few years. I was prescribed WB as I found in the winter that I would feel more depressed because of gloomy weather and lack of sun. I want to quit smoking and go on Chantix but can’t if I am on WB, so I started tapering over a month ago. Every other day I’ve skipped a pill for a month. Now I am every two days take a pill. The only side effect I have is lethargy, but I think that is partially due to my cat that wakes me up every night at 5 AM (LOL). I am going to continue tapering slowly each month until I am done. I have tried going off all meds but that was a disaster! Good luck to everyone!

  • Prismv February 20, 2015, 7:20 pm

    I’ve been tapering off WB 300mg for two months. I went on 200 mg for a month, and then 100mg. Only at 100 mg did I experience body aches, lethargy, fatigue, clumsiness, anger, irritability and anxiety spikes. At the end of each day, my body felt as I had worked out for 4 hours non stop, and the angst was at its worse. I suspected the meds were doing it, but since there was no improvement, I decided to stop after 2 weeks on 100mg. I have felt much better since. I think it would have been better to taper off quicker or go cold turkey. I think cold turkey you are just done with it once and for all.

  • Greg March 18, 2015, 11:13 pm

    I’m was on wellbutrin for just short of four years, as an ADHD person I was taking the highest recommended dose 450 mg for the better part of three years. I have come it to a financial issues, so no money no wellbutrin. Irregardless there is a symptom that they neglected to cover, which I have found the most difficult to deal with during the first week or two.

    A type of Lucidity during REM sleep which seems to cause both an intensity during the dream state which can be at lest troubling to highly distributing. This is couple with a high level long term memory retention usually found in stressful or dangerous recollections in your youth. I would hazard a guess that the low level dopamine in the amygdala is resulting and increase flight or fight response in the REM state and is also increase of long term memory consolidation in prefrontal cortex.

    Similar to an article I have been reading called “Epigenetic of the glucocorticoid receptor in the in the human brain associates with childhood abuse (McGown PO, Sasaki a, D’Alessio AC et al. Epigenetic regulation of the glucocorticoid receptor in the human brain associates with childhood abuse. Nature of neuroscience. 2009;12(3):342-348 doi:10. 1038/nn 2270.)” Please be aware of the possibility of this withdrawal symptom.

    • Nicole March 21, 2016, 10:55 pm

      Hey I know this is old, but you should look into the Wellbutrin Guarantee Program. Worst case scenario you pay $50 for your month’s supply instead of like $1,800. Good Luck!

  • Shelby March 19, 2015, 1:59 pm

    Okay, I am totally freaking out after reading the blogs. I have been on 150 Wellbutrin, 200 Zoloft and 1mg of Xanax daily for 12 years. Saw my shrink 4 days ago and talked to him about the possibility I am going through menopause due to moodswings, anger, anxiety. He told me to stop taking the Wellbutrin immediately. I asked about tapering and withdrawl symptoms and he said no need, not to worry. So far I don’t feel that different, but YIKES!

    • TankSubs March 8, 2016, 1:54 am

      Be careful. Sometimes withdrawals hit up to 2 weeks after last dose. Mine were SEVERE Muscle aches and inflammation in thighs and lower back, anxiety attacks that came in short but serious bursts, Pounding nightly migraines and MAJOR return of appetite. Was on Wellbutrin 300 XL for 3 months, ran out of prescription and my Dr was on vacation.

      Went through 6 days of torturous aching, worst around 6am-9am before Dr got back and wrote me refill. Still took 3 more days taking it again before pain was gone. Please taper off, unless your VERY lucky, it’s quite similar to the muscle aches from opiate withdrawals.

  • Alexey March 23, 2015, 8:45 am

    So I took this med WB 100 mg (the IR or ER) or which ever one is in the middle not extended and not immediate, or something for a week stopped it 3 days ago. The doc told me I could go cold turkey (I did). I have all the symptoms, even loss off sex drive, followed by a plunge into such horniness that I am “bi” for the moment. I found this site after my doc said it is not withdrawal from WB and tried blaming it on a “bad batch of weed”… I hadn’t even smoked that day.

    (My roommates smoked it, it’s fine). I took vyvanse in high school for about a year and a half. I was affected very severely by it, so I might be sensitive to stimulants. My question is why is it was affecting me so harshly, especially in the morning. Why did it come on in waves were I feel relatively fine and all of a sudden I got a flare ups. I am I getting seizures occasionally? I get extremely tired all of a sudden and black rings around my eyes, my roommates and fiance told me I look like I haven’t slept in days.

  • Joni Morden April 6, 2015, 4:51 am

    I have been on 100 mg extended release for 2 months. Didn’t like the blurry vision and stuttering it caused… so I stopped. Have started having panic attacks and dry heaving and shaking and shivering. Unable to control my body temperature. Almost went to the hospital today. Then realized that the difference was I quit the wellbutrin. Should I take one and contact my doctor about how to get off. Didn’t realize it was addictive. Or am I almost past withdrawal? Symptoms have been very serious and getting worse. I didn’t realize that is what is wrong with me. My employer is getting angry at me.

    • TankSubs March 8, 2016, 2:04 am

      How long since your last regular dose? Taking 1 pill after stopping for more than 3 days won’t do much, it takes a few days (doses) to build back up and affect dopamine and norepinephrine levels. I was forced to stop cold turkey from 3 months of Wellbutrin 300mg XL, I ran out of my script and Dr, typical, was out of town on vacation.

      I was fine for 3 days, then it hit me like a speeding freight train. UNBEARABLE muscle pain and cramps in my thighs and lower back, anxiety attacks like I couldn’t breathe, huge hunger pangs, migraines at night, every night, chills… Resembled overall milder opiate (vicodin) withdrawals. 6 days of that then I got another script, took 3 more days being back on it building back up dopamine and norepinephrine levels before the symptoms all just disappeared.

      Taper… Taper… Taper… off of Wellbutrin, please, do yourself a huge favor. If you don’t I hope your WDs aren’t like what I went through.

  • Tess April 21, 2015, 3:32 pm

    I take 100mg and I jave been on it for a little over a year. I did cold turkey once and it lasted maybe a month. I cried a lot, very impulsive my boyfriend would say, agitated, and angry. On top of all that my mind raced like crazy. Just now found out I was pregnant and the doc tells me to go ahead and take it and that they will wean me off closer to delivery. My question is do you know anything about this medication and pregnancies? I’m second guessing myself on taking it much longer.

    • twoods May 15, 2015, 4:04 pm

      My doctor told me it wasn’t safe during pregnancy. They switched me to Lexapro the second I found out that I was pregnant.

  • shara April 25, 2015, 9:09 pm

    I have been using Wellbutrin for just three months 75mg daily. I missed a dose yesterday morning and after few hours, I felt very dizzy and confused. I had coordination problems. I could not walk home from work! Finally, In home I tried to make some coffee and I felt vertigo and dropped boiled water on my legs and burned myself!! I really terrified after these symptoms. If withdrawal with such low dose and short duration is so hard, how can I ever quit this medication?

  • Jac April 29, 2015, 3:34 pm

    I really feel for everyone posting here. I feel like our doctors were so nonchalant about putting us on these meds and now we’re trapped! They really need to do more research on stopping medications. But the drug companies don’t care about that… They want you addicted and to continue taking their meds. My story: I think I started Wellbutrin XL June 2013 first at 150mg (for like a week or couple of days) then at 300mg for a while.

    Eventually my crazy “out there” psych put me up to 450 which was nerve racking because I had benign seizures as a kid. Then this Jan he put me up to 600mg! It worked for about a week or two and then stopped. Oh forgot to say, I’m on it for ADHD procrastination/motivation. I decided I want to start weaning off most of my meds (I’m on 5 psychiatric ones, plus two others for other reasons) I’ve started with Abilify but I’m nervous for Wellbutrin as well.

    I’m not sure if I should do one at a time, how slow I should go (I only have 4 months off school to do this). I’m going to see my GP tomorrow to ask what to do and get smaller doses so I can taper down. I’m also hoping she will give me Clonazepam for the anxiety I’m going to go through. (I also have GAD). If anyone wants to chat or support one another feel free to email me. (jaclyn.atkins@icloud.com).

  • b jordan May 11, 2015, 2:27 am

    Only on it for a couple months and now that I’m off, I’ve had a constant headache for a week! Worst headache I’ve ever had! Lots and lots of Excedrin aspirin and ibuprofen – barely helping. HELP.

    • Adriana December 29, 2015, 1:08 am

      Hi, Today is day 4 of weaning off bupropion Hcl XL 150 mg and my headaches have finally stopped, I am not as angry and edgy but still feel out of sorts, the only side effect that is bothering me a lot is the bloating and shortness of breath. I am sure your headaches will be ending within the next week and I am wondering if you felt bloated too

    • TankSubs March 8, 2016, 2:07 am

      Migraines and severe thigh and lower back aches, painful. Yes sir, you’re correct.

  • Cat May 25, 2015, 6:16 am

    I just quit 450mg cold turkey about two weeks ago, (I know, going 450 -> 0 is a terrible idea but oh well) and I’m currently experiencing a very bad wave of depression. I’ve been going to the gym at least once a day—every day—and have been maintaining a healthy diet, so I’m hoping it’ll end soon. I haven’t experienced any weight gain yet, but I’m worried I will… I’m determined to be off of antidepressants for the rest of my life, so hopefully the symptoms won’t worsen.

  • LW May 28, 2015, 3:30 pm

    I “accidentally” went off cold turkey from 300mg XR about 4 years ago- my husband ended up in the hospital unexpectedly and I didn’t remember to bring the meds (it was urgent but relatively minor surgery, so overall, not really a big stressor). I thought, eh, I’ve been wanting to talk to the Dr about discontinuing anyway, so let’s see how it goes.

    On day 6 I spent a pretty big chunk of the day curled up sobbing on the floor and I KNEW there was no reason for it but could not stop. I knew even in the midst of it that it was due to withdrawal, but OMG the withdrawal was TERRIBLE. About a year and a half later I ended up taking it again after some major life changes; now I’m hoping to taper off after 4 years but very wary and definitely going to taper slowly. I can’t do that again!

  • Deanna June 2, 2015, 8:57 pm

    I had been taking welbutrin xr 300mg and Zoloft 200 mg. I forget to take it often so I felt quitting it wouldn’t be so bad. How long will I be dizzy? Out of financial reasons I had to stop it. I’ve been on it for around 8 years. The dizziness is horrible.

  • Spencer June 14, 2015, 2:30 am

    I was on WellbutrinXL 300 MG for 10 years. Quit cold turkey and out of the blue, my girlfriend broke up with me. The breakup had nothing to do at all with quitting the antidepressant but rather an unrelated issue. Went through major depression, anger, sleepless nights, anxiety, aching all over, and always on the verge of tears. Its been 5 months and still suffering but not as bad as at first. It was NOT PLEASANT, to say the least. I would never go cold turkey again.

  • Jess June 23, 2015, 5:07 am

    I have been on bupropion 300mg for maybe 6 months(?) I was on 150mg for a month first then switched up…. Helped with depression but I got irritable so easy I noticed, but then wasn’t sure if it was just being a new mom and having a 1 yr and 2 yr old. I’m usually so patient so I didn’t like this at all. Anyways I read that people have had anger and irritability as a common side effect and when I forgot 2 days in a row to take it I just decided to stop. That was 5 days ago I believe and I have had a slight headache but I get those easily so I’m not sure if it’s part of it…

    I now tonight feel like I am getting a cold since my body is starting to feel a little achy. Reading these side effects are starting to make me a little nervous. When do the withdrawals usually kick in? Can I be starting them now after this long? I see my doctor in 3 days so I’ll be able to talk to her but does anyone know of anything to make the withdrawals easier other than to take the med? I never did get energy from them which I was hoping for and still tired. The last few days I have been a little more tired also so it’s all making sense if that is part of it.

  • Amy July 7, 2015, 5:31 pm

    I went off of 200mg of Wellbutrin after 8 years. The worst side effect of this going off was the fatigue and some emotional ups and downs and crying spells. But this drug made me crave alcohol like some antidepressants can do. That isn’t the only reason for going off it. Antidepressants are a billion dollar a year industry and doctors put people on them for all kinds of reasons.

    Some people really and truly need them. I had a time when I truly was anxious in a bad marriage but that time passed and I continued to take them because trying to quit was hard, like anything else. The first two weeks were literal hell, but I got through it. It’s been about a month and feelings, emotions, complete thoughts and memories have returned. I don’t feel as if I am on autopilot going through daily motions anymore.

    It is normal to experience ups and downs, that is called living. It is not normal to be controlled by a drug that shuts down your emotions so you don’t feel. I, for one, am happy to be off of this drug. It gets a little better every day. This is just my opinion and like I said, it is very hard but nothing worth doing is ever easy. I hope this helps at least one person that really wants to quit these drugs. Good Luck!

  • RB July 13, 2015, 1:30 am

    Great summary of withdrawal from Wellbutrin; very helpful. Thank you! RB

  • Dasani July 23, 2015, 2:57 pm

    I quit WB 300 XL cold Turkey a week ago. I lost my rx and decided not to refill it after a year of taking it on and off. Physically I am suffering. I feel nauseated, dizzy, diarrhea and can barely walk a straight line. I didn’t expect to feel this way. Mentally I am suffering because of the physical pain of nausea and dizzy spells.

    It’s to the point that I need to work from home. Sending emails are difficult…does this post even make sense? I can’t stop WB and expect to keep a successful career. I am so worried…I am scared and sad and feel so unproductive. I consider myself very disciplined and strong but had no idea quitting cold stalls my life this way. Thanks for reading. Any feedback is appreciated.

  • Tracy July 27, 2015, 4:13 pm

    I was on WB when I was age 23-26, my relapse was very bad at 35 with a traumatic life event. I have taken Wellbutrin for five years since and stopped about a month ago. Thought I’m in a good place in my life that I’m able to cope, didn’t want to be on it for the rest of my life considering it’s still medication. I tapered off gradually without much withdrawal symptoms EXCEPT now, a month later, I’m in shock by the amount of sudden weight gain.

    Literally everyday I step on the scale, I went up a pound it seems. So far I’ve gained closed to 8lbs on my 4’9″ frame at 115lbs as of today, combine with returning to school for months (sitting for hours on end), I’ve gained more than 12 lbs already and counting. Before medication I was 118lbs basically all my life, I lost 20 lbs as I was in extreme depression while I started, and gained back 10lbs overtime. I was hovering at 104 for these 5 years. Now only one month, I see my body changed so fast, I’m worried how much more I’m gonna gain.

    I no longer fit into my clothes, and have this general sense of shame about my weight… to the point I’m here trying to see what I take to the weight stop climbing. My diet has not changed, in fact due to a change of routine recently I’m eating less and moving more – but of course I gained weight. I didn’t suddenly have a crazy appetite since I finished with the meds. I do core strengthening exercise due to a back injury which I’m yet to restart.

    I’m not feeling my best walking around in this weight, and turning 40 doesn’t help my metabolism I’m sure. As I’m reading all the side effects I don’t think it’s that “bad”, but it still is medication that I’m not sure if it’s wise to be on for a decade or for the rest of my life? I’m not seeing depression signs that validate getting back on it. I have worried about the chance of relapsing hence taking it for this long (according to my doctor).

    Does weight gain alone enough of a reason to get back on it? Does anyone have suggestions on how to combat the weight gain issue? The “baseline” is no longer me… I don’t think diet and exercise is cutting this scary sudden jump… It’s scary to think I’m suddenly putting that weight back into my body by doing nothing or the ordinary.

    • Ronnie April 6, 2016, 4:20 pm

      Did you ever lose the weight you gained when you went off WB?

  • Lisa August 30, 2015, 10:37 pm

    Just wanted to say thank you for this site! I feel so much less alone. After taking Bupropion 150 mg for 8 years, I used the last of my prescription about two weeks ago. I’m an American living in Spain, and my doctor is on vacation for a month! I thought I’d wait it out, but I’ve been feeling absolutely bizarre–my old depression symptoms have come back (fatigue; feeling alternately numb or inexplicably sad; not wanting to leave my apartment; etc.), along with headaches (just the first week), insomnia, mental fogginess, irritability, rash decisions, and anger. The last two really surprised me! I’m so relieved to know it’s a common part of withdrawal, and that I’m not the only one who has experienced such intense emotional side effects. Thank you to everyone who’s shared their stories!

  • Susan August 31, 2015, 1:41 pm

    I, too, am so grateful to have found this site. After taking 300mg of WB for about 9 months, I tapered down and completely off about a week and a half ago. Tapering is designed, I am sure, to prevent unpleasant side effects, but I am thinking now that I am experiencing unpleasant side effects even though I tapered. All I know is that I feel weirder than I think I have ever felt in my life, and NOT in a good way.

    I have wondered if I am having a nervous breakdown. I keep crying, and my mind is constantly racing — always about negative things. As I sit in the morning with my coffee, I cannot imagine summoning the energy to get through the day. I actually found this site when I was trying to find out if leg cramping is a side effect of withdrawal. I don’t think my diet or hydration has changed in any way to account for the severe leg cramps I get at night.

    Reading what others have posted is giving me some hope that maybe this intense feeling of anxiety and depression will ease, although what it will be replaced by remains to be seen! Though finding the energy is a huge obstacle, I will try to follow the advice of others to get involved in some positive activity/exercise to get through these days, and try to keep hope that there are better days ahead.

  • JT September 6, 2015, 7:14 pm

    Hi. I stopped taking 150mg XL 3 days ago. I was on it for <4 months. I have a little HA that just started on day 3. I didn't taper, just quit. I slept in this morning and had my first morning and night of sleeping pretty hard! It was just a nice change! I didn't have weight loss or loss of appetite being on it, and had fatigue the whole time I was on it. Being off it, I have more energy on day 3, less of an appetite as well. I think I responded different to the med since I have ADD… Or used to as a teen. And still have trouble focusing at times. Do you think that's why I responded opposite as far as appetite, and fatigue go?

    • Rebecca December 19, 2015, 1:12 am

      I’m currently trying to wean off of the 150 XL. I’ve been on my 4 months and usually take before bed because it makes me tired. Makes me feel depressed. I got on it to help with my low libido. But I’ve yet to see an increase. In fact I have less interest in sex. So I’m putting days between each pill. My last time I went 4 days and when I took it I got that horrible headache I had for a month when I started it. I think I’m just not gonna take it again.

  • Chris September 8, 2015, 9:39 pm

    I have been on welburtin 150 sr for 28 days. Decided to get off. I stopped cold turkey and have been dizzy and vomiting sense. How long before it goes away? My upper chest feels like someone is sitting on it and my back hurt while on it

  • cyndi September 20, 2015, 7:32 am

    I have taken WB 300 XL for 10 years I believe. I have gained weight, depression still around so I decided to stop taking. I went through the crying stage and now it seems like I can not remember anything! I was trying to remember a co-worker’s name tonight and could not remember her name at all! It’s scary…

  • Grace September 21, 2015, 3:28 pm

    My new doctor, I don’t know why, wants to take me off Wellbutrin, which has worked well for me. I am having major problems. I have anxiety- she also cut my Xanax way down- developed a bad case of hives first time in my life. Intermittent tremors in my hands, a tic in my face, deep depression, loss of desire to move. Could these things be the loss of Wellbutrin? I’ve been on it for 10 years.

  • Kilimanjaro October 10, 2015, 1:18 pm

    Thanks god I found this blog! I decided to cold turkey this drug after reading your comments. I have used Serroquel for 5 years and started to tapering off it. I stopped at about 4mg but then experienced awful withdrawal syndromes. My doctor then prescribed this drug instead and I’ve used it for 2 weeks in the morning but skipped some days. I start taking Serroquel again at a very low dose (1-2mg), whether that’s the reason why I’m not having any problem with quiting bupropion or because of the short time using it, I don’t know. But I really don’t want to have the withdrawal effects like I had with Serroquel, so stopping this drug would be a good choice!

  • Mary Ann October 14, 2015, 9:57 pm

    I was on Welbutrin for about 10 years, 300 mg, then down to 150 mg for about 2 yrs. Didn’t feel it was having much of an effect so quit 6 months ago. Big mistake. I felt fatigued, sort of frozen with regard to taking care of some random tasks, had no joy or ambition in life. I too tried many supplements which I still take, but nothing seemed to help & my medical provider put me back on Wellbutrin.

    She said I will probably have to take it for the rest of my life. I didn’t even connect how I was feeling with buproprion withdrawal as my primary sxs were apathy and fatigue. I hate that a substance could affect neurotransmitters long-term and maybe even permanently so that I can never get off it! I have heard that it takes recovering heroin & other opiate addicts a year to go back to producing dopamine at the level the were at before they started using.

    Maybe antidepressants are the same and it takes a year for neuroreceptors to return to their pre-medication level. Anyway, accept that when you decide to quit this med, you could be in for a very hard time for quite awhile. I struggled for six months bf throwing in the towel & going back on it.

  • MiMi October 26, 2015, 12:30 pm

    I’ve been taking WB and Zoloft for the last 6 months. Prior to that I was taking Zoloft and Paxil for 20 years. 2 weeks ago I ran out of my WB so for 3 days cut the 100 mg in half 2 x day. I also did the same with my zoloft. I have been free from ALL drugs for two weeks. I’ve replaced all my medication with an increase in weight lifting and walking daily. I’ve never felt better. I have tons of energy, am not fatigued until bedtime, and eat properly. I’m hoping these good feelings will continue.

    However, I have those waves of depression on a daily basis, usually around 3 pm. That’s when my walking and weight lifting takes over. Am I unusual with my own side effects of going cold turkey with all my medications, or is it different for everyone? I must mention, I do take Trazadone before bed on a nightly basis, and have been taking it for 20 years. I wake up energetic and alert, ready to start the day. My question is: As time goes on, will I get all the side effects of withdrawing from the meds cold turkey?

  • Linn November 5, 2015, 7:36 pm

    I have been on Wellbutrin 150 mg twice a day for almost 16 yrs now. I tried quitting cold turkey a few years ago and felt like I had the flu and gained 5 lbs in a week. About two years ago I tried to taper off very slowly. I was doing ok exercising regularly and eating healthy with no weight gain. A series of stressful events came up and I couldn’t handle it so I went back up to 300 mg daily.

    Just a few months ago I decided to try tapering off again. My doctor cut me to 200 mg within two weeks and I had anger, insomnia, crying spells, depression and low energy. So I went up to 250 for a month feeling much better. Now I’ve been on 225 mg for two weeks and I’m stable. I’m doing Hot Yoga 3-5 days and week in addition to cardio 2x a week. I am taking SAMe, vitamin B, thyroid stabilizers, 5HTP and L Tryptophan for the insomnia.

    I’m thinking I’ll stay on 225 mg until the holidays are over. I’m scared of the rapid weight gain, crying spells and low energy. I can’t afford to loose my job! I’m praying I can do this tapering. I’d be happy if I could taper to 100mg and stay there.

  • Nancy November 7, 2015, 12:18 am

    Like everyone else, glad to have found this blog. I’ve been taking 100mg twice a day for 5 yrs, feeling like it’s time to come off for financial reasons and like others just don’t want to be dependent on a drug anymore. I recall when I started Wellbutrin I couldn’t do the full dose right away, I had to do it VERY gradually to be able to tolerate the side effects you get when you first start. My doc was very good about working with me on the dosing but seemed surprised at how “sensitive” I was but it worked.

    I started with 75 mg tabs and cut them in quarters, gradually worked my way up to 100 mg twice a day. I’m trying the same approach with weaning off. I’m down to 1/4 tab once per day, then I’ll do every other day, then every third etc, will take a while to get off. After reading everyone else’s comments with withdrawal symptoms I’m thinking that most folks are coming off too fast.

  • Nancy November 7, 2015, 12:57 am

    Glad I found this blog. I’ve been on Wellbutrin 100 mg SR twice a day for five years, started taking it during a divorce after 20 yrs of marriage. Fortunately, a family member who’s a psych nurse encouraged me to take it even though I was “embarrassed” to go on drugs. Best thing I did, it got me through the most difficult time in my life. For the most part, being on Wellbutrin has been a positive experience with only a few mildly annoying side effects, once I got past the initial start up period.

    You’ve got to give your body at least 2 weeks to adjust. Recently I decided I’d like to come off for financial reasons as well as just not wanting to be dependent on a drug anymore. When I started Wellbutrin I went very gradual, starting with 75 mg tabs cut up into quarters, until eventually holding at 100mg SR twice per day, anything higher than that was just too much. I’m weaning off now the same way, it’s taking months, my choice.

    So I’m down to 1/4 of a 75mg pill once per day, will go to every other day, then every third, might stop at that point, depends on the symptoms. Wondering if I’ll have to go back up because I do get SAD in the winter. If I do go back up then I’ll wean off in the spring. After reading everyone’s posts, I have a feeling most people are weaning off way too fast. Weaning down to the 75 mg tab, then cutting the 75 mg tab up has worked for me.

    Please note: DO NOT Cut or crush the SR or XL tabs! They are not meant to be cut or crushed!

  • Marvin November 10, 2015, 4:06 am

    I was on Wellbutrin (Bupropion) for about two months only, and I regret and curse the day I decided to take it! I came off cold turkey last week and been having the worse headaches, but that is not the worse, my mind is having horrible thoughts and I feel like two inner persons are fighting inside my head for attention. I feel like crying or breaking stuff up when this happens plus waking up in the middle of the night with a nightmare. NEVER had that before…has anyone experienced something similar? Help please!!!

  • Rebecca November 10, 2015, 2:19 pm

    I have been on Wellbutrin XL (150mg) for about 12 years. I really do not want to be on it anymore. I have tried several times to come off of it, only to have severe depression begin (that I truly believe is more due to withdrawal than anything else). Is there anyone on here that successfully came off this medication that was on it for many years? If yes – how did you do it and what happened?

  • Rita Rutherford November 11, 2015, 9:26 pm

    I went off Wellbutrin cold turkey about 1 month ago. I replaced it with some dietary supplements & essential oils. It felt like the “fog” has been lifted. I feel a lot better now, however I have gained 15 lbs in the last month. Not happy about that, but I’m hoping the weight will come off after my body gets used to being drug free. I may have to start watching my diet a little closer. #drugfree #worthit

    • LJ December 28, 2015, 11:59 pm

      Hi, I was curious what essential oils & supplements you’re referring to exactly and how you’re using them? I am on day five of going off bupropion 150xr and am hoping to find natural ways of easing the withdrawals and “cold turkey” symptoms. Any input is appreciated. Many thanks.

  • Aliciahelen@msn.con November 15, 2015, 5:04 pm

    I feel obligated to tell my story… NIGHTMARE! So On Wellbutrin for over a year (150 SR *2 per day), the pharmacist says there’s a pill that you can take so you can take just one (300 er *1 per day). This sounded more convenient so I did. First I noticed hair loss so I said it must be the drug. Then I said I think I’m going to go all natural and just quit “cold turkey”.

    Night sweats, hot flashes, shortness of breath, heart palpitations, irritated eyes, insomnia, lack of appetite, diarrhea, etc. I’ve went to the ER since I’m only 34 and was not expecting a hot flash! They are so scary! But then the night sweats and not being able to breathe. It’s been two months since I quit and I’ve been to the ER 3 times!!! Feeling like I was about to die. I think your brain has so much to do with your health and this drug is freaking scary!

    I am feeling much better but I had to cut out all bad foods. My diet is so strict, no caffeine (matcha is OK), minimal sugar, no alcohol, no drugs. I did further testing with my regular doc and my cortisol came back high. So this is why I changed everything! I also couldn’t workout! Like no weights, just yoga and walks. I think it has something to with my cortisol also. I needed as much Zen as possible and I am getting better.

  • Patia November 19, 2015, 10:59 pm

    I only took wellbutrin 100 mg for 5 days!!! Quit cold turkey about a week and a half ago because of bad side effects…I had so much energy during the day then would cry all evening. Just horrible!! Now I still a week & a half later still feel crazy, foggy head, like crying for no reason & main thing I noticed is psycho anger for no reason…I have a 5 year old daughter & feel so bad trying to explain to her that I will feel better soon! Reading these posts is so nice to know I am not alone :).

  • Michele Bellon November 20, 2015, 2:19 am

    I’ve been on wellbutrin xl for over 2o years (two 150 mg tablets / day. I took 450 mg for a few of those years). For about 2 weeks I have been unable to get the wellbutrin from the patient assistance program and had to take (the generic) bupropion xl 300mg once a day. I began having bad headaches, panic attacks that I’ve never had before, insomnia, drastic mood swings and significant tremors.

    I looked online, and even the FDA admits the findings that some brands of bupropion XL 300mg tablets are causing those same symptoms because it can release all at once, or not at all or…What I want to know is AM I HAVING THE SYMPTOMS FROM WITHDRAWAL FROM WELLBUTRIN OR FROM TAKING THE BUPROPION 300 XL? Scared. I am a caregiver and I have to function. What should I do?

  • Violet November 24, 2015, 4:11 pm

    I have been taking wellbutrin for 15+years. I was up to 450mg/wellbutrin and 20mg/cipralex once a day. It’s been 2 weeks and my detox is horrible. I am always hungry and feeling very irritated. My treatment is now being handled by medicinal marijuana through the local trauma center but I do not have the process finished until the new year (2016) any suggestions for the nausea? I finally have my sex drive back at age 48.. that was enough reason for me to stop prescription drugs entering my body but… blah!

  • Rachel November 26, 2015, 5:01 am

    After reading these posts, I am very worried about not taking WB I have been on 300 mg xl for like 10+ years & 40 mg celexa. For $ reasons I am ready to go ‘cold turkey’ on both, but I am terrified of my depression feelings coming back and now the withdrawals! I have been on some sort of AD med since I was like 16, so now after 16 yrs (now 33 yrs old) of being on meds I am curious to know if I still really need them.

    • Alyssa April 16, 2016, 2:37 am

      I don’t know if you will get this or not. You posted this a while ago. Whatever you do do not go off both of your meds cold turkey. I have been on meds for depression and anxiety for 17 years since I was 13. I’ve trialled getting off them but the depression came back bad.

      If you taper off one at a time it will give you a chance to see how your brain reacts. But cutting cold turkey could send you into a really bad depression that could last months. Trust me don’t do it all at once.

  • Kristen November 27, 2015, 12:23 am

    I’ve been on Wellbutrin for years – somewhere between three and four. I’ve been on the generic of 300XL and since stopping it seems as though my metabolism has been damaged. I’ve been taking a multi, l-tyrosine, megadoses of EPA:DHA, co-q-enzyme (the actual name escapes me), and sublingual b12. My depression has yet to return and I’ve been focusing on my sleep, using a light therapy box, and exercising more.

    Even with eating less and very nutrient dense foods I keep gaining weight. It’s not bloating as I’ll drink plenty of water and take diuretics yet to no avail. I’ve gained 16 pounds since shopping Wellbutrin and I’m ready to go on it for the weight loss effects alone. I was originally on it for binging and I haven’t had a single binge episode since stopping yet I can’t stop gaining weight. I had my thyroid levels checked and while the doctor wouldn’t tell me the actual levels she said they were normal (thyroid problems run in my family).

    Does any body have any advise? Rapid weight gain is – ironically – a huge binge trigger and I don’t know what to do about it. I’m growing to loathe my
    Body which is making things worse. It seems as though my metabolism is worse than before and I’m beyond fed up. For a number of years I refused to take psych meds and I highly regret even giving them a try now.

  • Mary December 5, 2015, 7:43 pm

    I am currently taking 150 XL, and I hate it! I have a past history with an eating disorder, chronic migraines (started when I was a child), anxiety and insomnia before this medication. Now that I am on this medication it has gotten worse, and my doctor won’t listen to me. I want to wean myself off of it. Any advice? Evidently I need a new doctor.

  • Denise December 7, 2015, 6:06 pm

    I started taking 150 mg. of Wellbutrin XL on Oct. 20 and I didn’t feel any different so on Dec. 3 my doctor upped the dose to 300 mg. so I’ve taken it for 4 days. Last night I had severe depression and a nervous stomach. Pretty scary. I want off of this drug so my doctor told me to go back to the 150 mg. for 5 days and stop. I was once on Zoloft and had to wean off of it. From reading all the blogs, it appears that because I’ve been on it for such a short time that I may have no symptoms. Today was the first day I took just one (150 mg.). He said if I’m not comfortable with 5 days then I can take it for 10 days and stop. Can you tell me if this is correct?

  • Alonn January 6, 2016, 3:39 am

    I was finally able to quit bupropion after being on it for 3 years. I had tried many times before and I wanted to share my success this time. I was on 150mg of xl. I first switched to the Sr version (75mg twice a day) for 4 days. I then continued the same dosage every other day for a week. Then, every 3 days for about a week before stopping completely.

    I believe it worked this time because I made sure to exercise (strenuously) 5 times a week. I may have gained a little weight back, but the exercise is helping me keep things in check. I also tried to really encourage myself and celebrate my success. Exercise (heart rate up!) is key!

  • Sarah January 24, 2016, 6:13 pm

    Has anyone experienced extreme paranoia while being on Wellbutrin XL? I convinced myself in my mind that my husband was going to leave me or divorce me when I was pregnant. Then after I had our baby, I still convinced myself he was going to divorce me, etc. It became an obsession with checking his phone, looking through his car, checking receipts, etc. I can’t control asking him questions if I have a thought in my mind of doubting him. It is literally tearing my marriage apart and I am driving him insane. Anyone else have the same problem?

  • Geo January 29, 2016, 12:57 am

    I’m on 450 mg. A 300 pill and a 150 mg pill. I ran out of the 300 and was only using the 150. Also was missing dosage 1 maybe 2 times a week. The past 3 days I been feeling like my body is here but my mind ain’t. Today I crashed I’m 30 years old and been on many pills. Most scariest experience of my life. Was at work and started feeling unbalanced then my job details I normally do I f*cked up and took very long.

    I left work and tried to drive to the hospital. I had 2 crying attacks in the car pulled over a block from the hospital and waited for my girlfriend who was 30 mins away ever though hospital was a block away… in the waiting room crying, like a full on cry for 30 or 40 seconds and then acting normal like sorry that wasn’t me doing that… crazy sh*t. Worst day today.

  • Lynn January 31, 2016, 4:11 am

    Thanks so much for all this information. I really wished my doctor would have told me that coming off this drug was so hard, I would have never started it. I am calling her Monday and going to come off. I have been having stomach issues and bad leg cramps and not sleeping, that is what brought me to this site. I was wondering if this drug had side effects that I wasn’t told about. I am on Bupropion HCL XL 300 MG been on this for about 6 months. Again thanks for all your advice.

  • Vix February 26, 2016, 5:18 pm

    So I have been taking Wellbutrin for many years. I also take Lexapro. In my estimation, I have more of an issue with anxiety than depression. Though the depression is very real at times in my life. I had weight loss surgery three months ago and my health is improving daily. I did not realize it, but my Wellbutrin prescription ran out and I can’t get in to see the doctor right now, so it forced me to go cold turkey.

    I was not prepared for that. I was taking 150 2x daily. I have definitely been having some withdrawal symptoms. One day early into the cold turkey I had a day-long crying jag. Most days I feel fine, but I have episodes of intense anger and/or rage that come and go. I just try to ride them out and recognize them for what they are. I have had headaches and dizziness as well.

    I am trying to figure out now that I am this far into it if I need to go back on them at all or try to do without. I went through two years of therapy and had the weight loss surgery, so life is much more manageable than it used to be. Anyone else take this ride and successfully come off and stay off the meds?

  • Laura February 29, 2016, 7:11 pm

    I am new to Wellbutrin taking 100 mg daily and at end of first week started having vaginal bleeding. I have learned this is a side effect of Wellbutrin but am unable to find if this goes away once my body adjusts to medication. Psychiatrist, MD and pharmacist unable to answer this. Has anyone experienced same issue?

  • Amy March 2, 2016, 3:23 am

    I have been on this med since 2003. Was taking 300mg XL a day then when I had my prescription refilled a mistake was made and I was taken down to 150mg XL a day. I didn’t necessarily have withdrawal symptoms like a everyone is describing, but I had suicidal thoughts. This lasted for about six months and I went back up to my regular 300ng XL a day dose and a lot of those thoughts went away, but I still had thoughts of suicide. So I went up to Forfivo XL which is a 450mg once a day and those thoughts are gone. Has anyone else had a similar experience with this drug?

  • Donna March 5, 2016, 1:51 am

    I took Wellbutrin since 2007. My last dose was 450mg daily. Due to financial reasons I had to go off Wellbutrin, cold turkey. It’s been about 4 – 6 weeks. OMG!!! Everything HURTS. Nausea is terrible. I really don’t eat. I get pins and needles, numbness in my extremities. My balance is terrible. I was having nightmares. Some nights I sleep well, others… I try to do things but am only able to spend short periods of time, then I have to go lay down. I just want this to be over. I’m kinda scared by what is happening. If all this is due to withdrawal I assume it will eventually stop.?

  • Belle March 7, 2016, 6:26 pm

    I was taking adipex for weight loss & then was prescribed wellbutrin for depression; I’ve since stopped BOTH MEDS cold turkey b/c I was having tremors (more at night) & less episodes during the daytime. I’m also on meds for diabetes, blood pressure and a couple of others. These tremors have now lasted for about 4 weeks – is there an end to this? Please, any advice is WELCOMED!! :) Were any of you (on this site) prescribed any meds to help with the tremors? This is driving me insane!! I sometimes wake up and just want to cry, other days, I shake uncontrollably…I just need this to stop!! Please Help!!

  • Johanna March 8, 2016, 10:02 pm

    Hi everybody, First of all I want to thank you all for sharing your experiences. Reading it helped me understand what I was going though and I’d now like to share my story. I was on wellbutrin 300mg extended release for 7 years. I had already been on setraline 150mg for 3 years but nothing seemed to help my very deep depression with a lot of suicidal thoughts and self harm, so my doctor decided to add wellbutrin to the mix on top of the setraline.

    Now 7 year later I got a different doctor (since I moved abroad from Sweden to the Netherlands) and for the first time someone actually took a good look at what medications I was using. Apparently wellbutrin is almost never used against depression in the Netherlands so he got very suspicious. We decided it was time to try to get off it since I was feeling better and we weren’t sure this medicine was actually was doing anything good for me.

    First I went down to 150 mg for two weeks, already after the first week I started to feel some psychological withdrawal effects, I got more moody and could have manic periods where I didn’t sleep and just stayed up cleaning or doing something similar. After two weeks I decided to go off it totally since the withdrawal was already quite bad I thought “how much worse could it get”, much worse I found out.

    First the psychological effects got much worse, with random crying and screaming, at one point I even screamed and cried at my partner because he told me to stop vacuum cleaning in the middle of the night. About two weeks after I had stopped fully the psychological effects were almost gone but the physical effects started. I was extremely nauseous, to the point where I couldn’t eat any solid foods for days.

    It got better after about 3 more weeks but it was still there, it took 5 weeks until I felt like normal again. I was afraid I’d get more depressed but now 4 months later I feel better than ever! It was terrible but without any doubt worth it in the end. What a ride it was, and not only for me but also the people around me. I was blessed with a very patient and supportive partner which really helped.

    Stay strong, keep on fighting and know that it will get better. Johanna

    • Debbie H March 12, 2016, 1:31 pm

      Interesting to hear that doctors in the Netherlands don’t prescribe Wellbutrin for depression. So, it sounds like you still take the other medicine but quit the Wellbutrin. Thanks for sharing your story and I’m glad you are feeling better now. :)

  • Debbie H March 12, 2016, 1:25 pm

    Thanks for everyone sharing their experiences. I have decided to stop Wellbutrin XL because I have alot of side effects that I guess most people don’t have. First I should say that this is my only prescription. I do take vitamins, when I remember. I don’t like taking meds but agreed to after not being able to treat the depression with supplements (like Sam-e). I started out on XL 300 mg and quickly found out that it was too much for me.

    I had an awful time falling to sleep and then would wake after a few hours. I was so tired and dysfunctional from lack of sleep and my heartbeat was so hard that I could feel it pulsing hard in my chest and a few times in my feet when trying to sleep. So, Doc switched me to generic Wellbutrin XL 150 mg. Side affects were anxiety, tingling sensation in hands mostly & tightness in chest and throat. Sleep got better but I did feel that generic Wellbutrin XL was not helping the sad feelings.

    So, I asked to be switched to the name brand XL 150 to see if that would make a difference. But it has not. So, today(Saturday) I am skipping it. Tomorrow, I may take it… I’ll see how I feel. And Monday I will call the doctor. My side effects now are about the same as on the generic… hands and legs tingle, but more prominent in hands. I don’t know why. Anxiety is greatly increased compared to 3 months ago when I took no meds.

    I had a bit of an anxiety problem before… but meds have made it 10 times worse. Usually, by mid-day, I feel like I’m in a fog… like I haven’t slept but have to be awake and I feel tightness in the upper chest area to mid throat. Also, my neck aches. Yesterday, I just wanted to be alone at work… but I can’t. I work at an assisted living facility and am around people all day… well, most of the day.

    I just want to stay home because I feel… strange, uncomfortable and sad. I cried driving home yesterday. I want so badly for this to work but I have just traded one set of bad feelings for another. I feel like everyone can tell that I’m not myself but I asked a nurse friend at work and she said that I look normal. Also, I have not lost any weight… but I haven’t gained either. I really need to lose quite a bit. ~Debbie

  • B. Frances March 19, 2016, 1:28 pm

    After happy highly productive life at one Retirement Home despite several fairly major surgeries change to another to be nearer close family member and suffering several month foot pain (curing myself after therapist, surgeons, pain doctors couldn’t think of the simple “cure” of just wearing a slipper!). Once I suffered depression when at a dreadful retirement home after loss of husband, and Wellbutrin cured that almost instantly when I left that place.

    Upon entering the new retirement home, visiting psychiatrist put me on Wellbutrin instantly, not needed because I was NOT depressed and foot cured. Also Clonezapam. After nearly three years of misery, have stopped Wellbutrin. Psychiatrist said to just stop Wellbutrin! Isn’t this dangerous? I have “tapered: it slightly and now stopped but still constantly nauseous and Clonazepam losing effectiveness.

    Question: Will awful effects of Wellbutrin ever stop? Anything to replace Clonazapan to help with nausea? Ginger, peppermints, etc. are useless. P.S. I am NOT depressed and have an active writing life. Just miserable from the nausea and some dizziness.

  • Tana March 22, 2016, 2:25 pm

    I have been on Bupropion XL for about 6years, once I got pregnant I was afraid of having postpartum depression so I continued loner than planned. I recently ran out of refills and thought I would stop taking it all together. It has been a little less than a month and I have been sick to my stomach frequently and moody. I am going to refill my Rx and continue taking it for now. I have a doctor appointment soon. Maybe it is the best thing for me. I did well on the medication but I just don’t want to be dependent on a medication my entire life.

  • kerry Mccarthy April 14, 2016, 5:57 am

    I took Wellbutrin XL 300mg every day for probably 5 years. Worked well and helped to bring me out of serious 10yr Depression. About 6 months ago I couldn’t take it any more because it hurt my stomach. So I took it as often as I could. Noticed within few days that my thinking was “slower” and I was VERY fatigued. By now I feel well mentally/emotionally but I’m still struggling with that horrible constant Fatigue.

    Tempted at times to take it again but I genuinely want to reduce the amount of Meds I take and do it safely and with Support. Being stable is even more important for me as I work in Mental Health as a Peer Assistant/Warmline Operator. So I wish all of you well out there: Educate yourself on ALl your Meds and seek support. All of us with Mental health issues can Recover/Improve and have a good life. God bless us all… Kerry

  • Alyssa April 16, 2016, 2:24 am

    I have been taking the generic of Wellbutrin 150-300mg since 2010. I was originally put on it to help try to boost the effects of Zoloft during a bout of major depression. Long story short after being on Zoloft for 12 years it stopped working and I was put on Viibryd. I have been taking both the Wellbutrin and the Viibryd since 2011.

    After discussing the two med with my mental health provider it was not recommended that I take the Wellbutrin if wanting to become pregnant. I was on 150mg xl most recently, tapered to 75mg for 3 weeks and 37.5 mg for 1 week. I didn’t have any withdrawal symptoms during this time.

    I now have been off of the Wellbutrin for 2 weeks and am experiencing brain fog, forgetfulness, trouble falling asleep, irritability and anxiety. I want to wait it out hoping my brain will take over and start making its own dopamine and norepinephrine but I fear the longer I wait I might hit a patch of actual depression. Anyone run into a similar situation?

  • Serafin April 16, 2016, 10:52 pm

    I quit Wellbutrin a little over 9 months ago. I’ve gained 20 lbs. Around the 3rd week after quitting, my panic attacks became less and less frequent. After the 3rd month, and ever since, my panic attacks are gone. I no longer have panic attacks. However EVER since, and it’s been 9 months, I feel like an empty shell. I don’t feel like myself, my attention span is minuscule, I’m always lethargic, I can barely get out of bed, everything feels numb and diminished, nothing makes me happy, and I’ve all but lost my libido. Hope this isn’t a permanent effect from the Wellbutrin.

    • Julie April 27, 2016, 6:22 am

      Hi Serafin, I’ve also gained weight, nearly 12 lbs, in the 5 months I quit Wellbutrin. It’s worrying. I’m still depressed and hopeless and utterly lethargic. I hope the weight gain stops soon, but the rest of what I’m feeling is probably depression and here to stay. Hope things get better for you!

  • Kristie April 25, 2016, 1:47 pm

    I have been on 300XL Wellbutrin and a low dose of Lexapro for several years. I cut the 300’s to 150 but didn’t realize that you shouldn’t cut the extended release pills. My doc prescribed 150 of the XL’s so I’m going to start those (and keep the Lexapro for now). I cut to 150 about six weeks ago and the first thing I noticed was the anger.

    I can manage that but it was a clear reminder of how passive I had become on the Wellbutrin without even realizing it. What brought me to this site was a search on dizziness related to Wellbutrin withdrawal. I was worried something was wrong with me and it dawned on me that it could be related to the withdrawal. Sure enough, I believe that’s exactly what is causing the dizziness.

    I hope it doesn’t last long but I’m determined to get off the Wellbutrin completely so I’ll taper as slowly as necessary. I appreciate reading all of the comments as it helps to know that you’re not alone when it comes to something like this.

  • Luna May 7, 2016, 1:58 pm

    I cold turkey quit Wellbutrin XL 450. It’s been 2 days and I feel great!! My hubby is super happy to see his wife back in life… I feel 1000% better, happier, focused, funny again :) :) :). And the most, I’m not depressed, no more unexpected crying. My emotional status is very stable, my confidence is back. Any questions? Feel free to ask :)

    • John June 17, 2016, 10:53 pm

      Luna, How long were you on it when you quit??

    • Shellie September 20, 2016, 4:02 pm

      Hi Luna, How long were you taking your 450mg? How have you been since? Glad that the first couple of days were good for you.

    • Shellie September 20, 2016, 4:14 pm

      I’ve been taking WB 300 XL for nearly 4 months (06/03-09/20) and am quitting cold turkey today due to financial reasons. I am feeling nervous and will check back in once or if I notice big changes to my mental or physical health. Thanks everyone – hearing your stories has been very helpful for me right now.

  • Elektra May 17, 2016, 10:28 pm

    Hey all, I’ve been off Wellbutrin for about a month now. It’s a long story, but I was put on it in the form of Contrave (bupropion/naltrexone) for weight loss, because I had gained a ridiculous amount of weight from a combination of antipsychotics and rebound weight gain after stopping Adderall. Unfortunately, while the Wellbutrin did suppress my appetite, I never lost any weight and it also made my hair fall out.

    It took me a while to figure out which drug was the likely culprit, and then another few months to taper down. I did have some anxiety/agitation coming off the Wellbutrin. I was on 360mg/day. The psych tried to put me down to 150mgXR, but this caused full blown withdrawal- anxiety, nausea, dizziness, sensitivity to light and noise, etc.

    So I was put back up to 200mg SR, where I stabilized, and then brought down to 150 mg, then 100mg, then off. It was sometimes difficult but manageable. My hair is still falling out, but I have read that this is normal up to four months after stopping the drug. Anyway, Wellbutrin was the third psych drug I have stopped taking after Adderall and Seroquel.

    In general, I find that tapering as slowly as possible and adjusting the dose if you are really withdrawing works. Good luck!

  • Carole May 27, 2016, 2:20 am

    I haven’t lost any weight from Wellbutrin and I don’t have a higher sex drive – maybe my depression is a little better, but it’s definitely not worth the side effects. I’m glad I found this site because I was going off it cold turkey!

  • Paul June 3, 2016, 4:25 pm

    Folks, I am on 150mg HC XL 2 per day. Financial circumstances have changed and I need to taper off & quit soon. I have been on about 3 months at 2 per day, prior 3 months at 1 per day. A while back, for 2 or 3 days, I was off because I had so many things going on I forgot to pick up refill. I did not notice any side effects.

    So, I am going to go to 1 per day for a week or 2 and then off. However, after reading a lot of these posts (no way to read them all), I want to bring something up that I feel is CRITICAL in this process and when taking ANY medications… something most doctors never mention. Every individual has a different body chemistry. Every individual has their own unique emotional state as well as unique issues both physically and mentally.

    No 2 individuals are exactly alike. NO, I do not have medical training, but common sense sometime trumps all that, especially with the state of medical affairs in this country (going downhill like a lead weight). What I have noticed in the past number of years is that more and more side effects are listed for any specific drug.

    I do not believe that is directly related to the drug itself, but more to offset potential litigation if there is a problem with that drug. Add to that all the drugs that are out there (old and new) and I am sure that the FDA is to be trusted at their word (only if you are completely gullible). New drugs are of particular concern as there is no pattern of long term use to guide you with.

    With all that said, as an example, if 2 individuals take the same dosage of the same Wellbutrin, one may have no side effects and the other may have all the side effects or something in between. So my suggestion is that anyone that is quitting this drug should taper in some fashion and just see, in each step down, how they are doing and what they are experiencing as they move forward.

    Keep in mind that any “symptom” you experience may not be related to Wellbutrin withdrawal but something new or something old that has come back. And, absolutely, do not panic about any side effects and calmly deal with them. This specific forum is terrific as there are many valid points and issues brought up but do not assume any given point is specific to you.

    Use the information provided as a guide and temper that with common sense. And most of all, find a GOOD GP that is someone you can trust and is truly concerned about your welfare. Sadly, they are few and far between, but they are there (I have one!!). Good luck to all!

  • G June 3, 2016, 11:01 pm

    I quit Wellbutrin cold turkey yesterday after over a year. My psych thinks I’m traumatized when it’s fairly obvious to me I’m somewhere on the spectrum. They put me on it due to schizoaffective symptoms due to stress and the situation that put me on it has long since resolved. I found it made me more even, but it just made it more difficult to sleep, gave me more tense muscles and didn’t help my brain functioning.

    I gained fifteen pounds and it felt like there was a wall between my logical thinking and my emotions. I began smoking marijuana daily to try and ease the muscle tension and allow me to sleep and cope with the Wellbutrin. Then after emailing my psych and seeing him want to refer me to someone else for an anxiety evaluation I had a meltdown and resolved to quit.

    I have been able to function decently prior without an antidepressant though they have had me on and off them for over ten years. I am taking 300 currently, so I took time away from work to try and ride it out and implement a routine and actually begin to do things that would begin to treat the actual disorder. Hopefully the symptoms aren’t so severe.

    These are the first days since I felt like I haven’t had to smoke Marijuana since I have been on it, though if the side-effects end up being severe I may have to use it to cope. Dreading next week.

  • Jimmy June 6, 2016, 3:44 am

    I have been on Wellbutrin XL 300 mg for just over 4 years for anxiety and to help with occasional withdrawal symptoms from the 32mg of subutex I take everyday to keep me off opiates. Three weeks ago I made the decision I was gonna get rid of pills in my life so I could lift the fog and stop skimming through the best years of my life on autopilot. I dropped to 20mg subutex and cut the wellbutrin out entirely.

    I came off of Paxil years ago and have been through 200mg+/day oxycodone habit withdrawals before. This is a cakewalk compared to those but its still very uncomfortable. My first 3 days were migraines. Then a few days that weren’t so bad. Now at the end of three weeks, the past 4 days or so have been hell. I cant sleep but I’m exhausted. I have zero energy or interest in anything.

    I’m constantly hungry (craving sugar and ice cream). I’ve had irritable bowels. My ears are ringing and my head is buzzing like a thousand bees in a sardine can under pressure. My whole body aches. When I manage to doze off for 15 minutes at a time (each night feels like it takes 3 days to get through) I have horrible, vivid dreams. I’m glued to the couch with ZERO motivation.

    I keep getting chills and the sensation that my nervous system is lit up like a christmas tree. And my throat has been sore all week. I didn’t know that wellbutrin had these kind of withdrawals. I’m just thankful they aren’t anything like hard core opiate withdrawals which are like a level 10 if these are a level 3 or 4. But how long will this last? Today is my @20th day and they’re worse than ever.

    I’m self employed and haven’t been to work in weeks because of this, a luxury I’m grateful for since I cant imagine trying to function at work. Thanks everyone.

  • Kenneth June 9, 2016, 8:07 pm

    I was taking wellbutrin for like 2 weeks I think and the only symptom I had was being very pissed off at random times. I have anger issues anyway but after I started taking wellbutrin for a while my family actually wanted to put me in jeuvy because I was being such a prick and all I could think about was working out and doing what I wanted. Anyway, I quit taking it for about 3 days and I started feeling depressed and bored with life (everything seemed to stand still and I felt lifeless).

    I started taking it again about a week ago, I feel better but I felt great before I stopped taking it the first time. I had motivation, wasn’t self conscious about anything and I wasn’t afraid of anything, I pretty much felt like I was on top of the world… But now that I quit for 3 days then started again, I’m extremely forgetful (like I can’t remember why I’m doing something sometimes and I get anxious (not as much as if I weren’t taking it). My anxiety is social anxiety BTW.

  • Tahina June 16, 2016, 8:21 pm

    I first researched withdrawing from Wellbutrin for a while before I went off it. I have been Wellbutrin free for over a month now with no side-effects, and wanted to share what I learned along with my own tips. I had been given 300mg EX for about a year. I decided to take the advice of an online Dr. and had my p-doc reduce the dose in half to 150mg EX for 10 days, and then just jumped off.

    Remember, you probably had a lot of trouble getting on the meds before they stabilized. However, you stuck with it because of the results intended. The cessation has far less side-effects, and once again you need or want the results of NOT using the medication any longer. So just stick with it. I found it very helpful to not be a hypochondriac and make too much of any suspected withdrawal symptom.

    If I had a headache or feel a bit dizzy, I just ignored it, and went on with my day. You can take aspirin or whatever, to counter headache as you usually would. Don’t acknowledge slight symptoms, real or imagined, or give them any power by trying to analyze them. I just told myself it was nothing or would be over quickly, and it went away. Continue to exercise, walk, play games or sports, read, write, draw, workout at the gym – and be sure to drink lots of water.

    I believed that it would be easy, and I could do it. Your mind has a lot to do with how you feel. It can convince you of sickness, fear or pain, or of health, motivation and feeling good. Don’t jump back on the meds just because you feel a little different or gain/lose a bit of weight. Your brain has to go back to processing dealing naturally without the chemical influence, so give it time.

    I wrote this in hopes that it would help others as it did me. I greatly appreciated the good advice I found and wanted to pass it on. If this works for you, pass it on as well. Best of luck!

    • John June 17, 2016, 11:21 pm

      Thank you for this post. See my story below…

  • John June 17, 2016, 11:50 pm

    This site is awesome and so glad I found it! My story. I work in a high stress IT job in a local K-12 district. Just been promoted to a supervisor type role and in charge of several projects, one of which is getting 3000 MacBook Airs ready for Student 1-1 use this fall plus 3000 1-1 iPads, So yeah a lot of stress… Been on Zoloft 100Mg for about 20 years due to anger outbursts/depression/anxiety issues.

    Works great. Had an anger outburst at work and some at home about a month back so voluntarily decided to go back to see a counselor. She suggested I get reevaluated by a Psy Doc. Saw Him last week. He suggests Wellbutrin 150MG XL to add to Zoloft to ‘smooth everything out’. On for only 10 days and have another anger outburst at work. Great, probably a discipline write up now. I have told boss about my issues last time-don’t tell a lot of people and I have been here 4 years in this District and this is the first time I have told anyone.

    Anyway have just about every side effect listed for Wellbutrin. Last night could not sleep at all plus very anxious. Just went off this morning after calling Doc nurse as stayed home from work today but still have brain fog and a anxiety. After reading this I now have more reading all of the reports of side effects from going off.

    On the plus side I do work out daily, take a bunch of vitamins and only drink water -64 oz a day- plus one cup of coffee in the morning and usually milk for dinner. I try to eat well also. So HOPEFULLY my withdraw issues will be minor. Question- for those that are employed how do you explain your anger outburst to your employer and fellow employees and that you are doing all you can to address but the meds are making it worse?

  • 10bac10 June 23, 2016, 7:04 am

    I have been off and on 300 mg XL for years now. I decided to give it a go without and started to taper by taking a pill every other day, then every two days, etc. If I felt any withdrawal symptom, I’d take one. That seemed to work pretty well for me. My intention was to go to the doctor and get 150 mg tablets and taper from there, but I couldn’t get an appointment.

    At some point, I hadn’t taken anything for a few weeks and went with it. John, I don’t know what you say to co-workers. Since you are in a school system, have you thought about speaking to the nurse? Maybe h/she will have some suggestions on how to manage the personnel part of your question. Good luck. This is not going to be as easy as I’d hoped.

    In the interim, I have had a migraine, some dizziness, terrible jaw pain, unexplained bruises, increased appetite, one whole body painful but quick cramp, and it’s 3 AM and here I am, awake. I also feel a little paranoid and forgetful. It didn’t occur to me that the migraine or jaw pain could be from the withdrawal until I discovered this thread. I exercise and eat well, etc.

    At this point, I don’t know whether to just hang in and see if this improves or if I should go back on some lower dose and taper more slowly. I had no idea the discontinuation could take so long! Any advice on how to proceed from here?

  • John June 24, 2016, 5:39 pm

    Just a quick follow up to the post I made a few weeks back and an update so my progress getting off Wellbutrin. So far I have had a few side effects going off the 150XL, probably since I was not on it for so long. But still some tiredness and fogginess in thinking which hopefully over time will subside… On work side I had a long talk with my Boss and it went well.

    He was VERY understanding. :-) In our small staff we are delegating more of my work load off and being placed on a strict 40 HR work week. (Was salary but do to government stepping in with another intrusive workplace law I am now back on hourly – which all things considered I guess if for the best in my case). Hopefully over time the work relationships will improve. Thanks all for the support.

  • Sara June 29, 2016, 11:36 pm

    I’ve been on bupropion XL 300mg for about 13 years (I’m only 33). I’ve been wanting to come off of it for a while BC the med was just thrown at me in the first place. I was given the 150mg pills 3 weeks ago and the withdrawal has been horrible! On day 4 I was so angry and the slightest annoyance would set me off.

    Day 5, I couldn’t get out of bed. I’ve been dizzy on and off the entire time but for the last week I’ve been so dizzy I shouldn’t drive and can’t think straight/concentrate. My brain has been in a fog a few times. I’ve been ridiculously tired and exhausted! My body hurts and have occasional headaches but that could be from lack of sleep.

    I want to come off completely but not sure my body can handle it. I can’t be like this much longer bc I have 3 kids under age 2.5! I’m relieved to read all these comments knowing I’m not the only one feeling this way.

  • Nick July 12, 2016, 5:23 am

    I started 100mg six years ago for anxiety/depression and was never really observed during this time. My primary care provider prescribed it in my old state, and my new PCP wouldn’t refill more than a month’s worth because she wanted me to see a psychiatrist. I did this for a few months but didn’t find the $100/month 10 minute sessions worth it so he cut me to 75mg once a day. 2 months of this I cut the pills in half making roughly 35mg doses and I’ve been completely off of it for 2-3 weeks.

    While on it I definitely felt that depersonalization feeling and never knew if it was me or the pill. Time will tell with that one. The biggest things I’ve noticed since quitting and tapering are what was close to bouts of uncontrolled panic like I used to have but I’d control it quickly. If been wanting to quit for years and had learned some meditation stuff and lifestyle changes.

    The biggest thing which could be unrelated is what I think are heat and stress hives on my hands and fingers mostly. They’ve appeared briefly on my shins too. There, yesterday, both legs were randomly covered in an itchy rash and disappeared in an hour. The pharmacist said it’s possible for it to be Wellbutrin withdrawal.

  • Mike July 16, 2016, 2:07 pm

    I had been on Wellbutrin for well over ten years. After a few years in doing fine on 150 dosage, I was switched to the generic by the health insurance. it was not doing as well, so went up to 300. Then a few years later up to 450. I asked my doctor if I cold drop back to 300 XR and really didn’t notice any difference at all in the drop. That was around five years ago.

    I called my doctor asking to be dropped down to 150 so I could taper off, but he was reluctant. Anyway, about two and a half weeks ago I quit the 300 XR cold turkey and have no (zero, nada, zilch) withdrawal issues. I really feel so much more in control and I’m glad to be off of it. About a few weeks before I made that decision, I started taking sublingual B12 to address a few issues despite my B12 blood levels to be well within normal range.

    It could be a placebo effect, but my energy and mood are improved and common bursitis flare up are gone. After a few days off of Wellbutrin, my tinnitus seems to be a bit better. I’ll continue to monitor myself, but so far everything is better than it’s been in a long time. I’m not looking forward to telling my doctor about going cold turkey and his reaction at my next appt. in a few months, but if that’s the only negative issue with quitting it, I’m fine with that.

    What’s he going to do? Say I’m crazy, impulsive, or reckless for doing that? He’s a psychiatrist. By definition most if not all of his patients should fall into at least one of hose categories. Going cold turkey can be risky and tapering off is great if your doctor is open to it. I wold not have done it if I was actually on Wellbutrin, but I’m convinced that I already went through the tapering off long ago simply by switching to the generic.

    And I don’t believe I was getting any real medical benefits from taking it and putting up with a few side effects (albeit mild ones). By all means taper if you can, but if you’ve been on the generic for a while, it’s worth trying a more aggressive tapering.

  • Eryn Kelly July 23, 2016, 10:50 pm

    Hi there. I’ve been on wellbutrin 150 xl for about 2 years and I kinda weened myself off by taking 1 every 2 days and the 3 days and then 4 and then off completely. I replaced it by St johns wort. The only symptom I’ve noticed is my sex drive which is basically non existent right now and for a 24 year old with a BF that’s not good… do you know how long this could last?

    Besides that I haven’t noticed any other symptoms and I’ve been off it for about a month. I also do try and stay positive and realize that I will have my off days (I’m bipolar) I am still on lamictal 25mg a day down from 50 so I guess that’s also keeping me sane. I want to eventually only be using herbs but I’m still too scared to be completely drug free.

    My reason was because I really just couldn’t afford the meds anymore… if there’s anyone else who could give me some advice it would be appreciated. TIA

  • Lisa Boseman July 28, 2016, 3:45 pm

    I had to go off Wellbutrin cold turkey since my insurance ran out. The major side effect is lack of physical energy – and inability to think quick on my feet. I am a public speaker and I find I just can’t get that zip and energy in my speeches like I did on it – it is like I have brain delay…

  • Melissa August 6, 2016, 10:43 pm

    I’ve been on WB-XL for approximately 4 months. It was combined with Zoloft, which I have been taking for years, because I was going through a rough time at work and not coping well on Zoloft alone. The WB helped initially but it’s not really making any difference now. So, I’ve decided to come of it. Since starting WB, I’ve had increasing AWFUL joint pain.

    It is so severe that my fingers and wrists ache virtually all day. I thought I might have RA but decided it’s the WB because it’s a known side effect of the drug. I can’t really taper the type I’m on but I’m going to give it a try or go cold turkey. Someone posted about having painful, aching joints so I wanted to state that this is a side-effect of this drug. To anyone trying to taper off, good luck!

  • Jack August 7, 2016, 3:32 pm

    I was on Wellbutrin for years for depression, got a sore on my leg that went septic on me and the antibiotics they gave me caused a reaction with the Wellbutrin so doctors took me off of it right now. Ever since then I can no longer take it or I get a reaction. Now I’m experiencing numbness in my feet and legs and have terrible balance. Is it possible that is from the Wellbutrin?

  • Janet August 8, 2016, 8:08 pm

    I have never taken the real Wellbutrin… have always taken generic Bupropion & its been over ten years. I see many of you are paying crazy high prices… I take 150SR 2X day… the price actually went down this year. I have no insurance. My cost is $20/month! So for those of you quitting because you can’t afford it… surely you can come up with $20???

    I too finally reduced my dosage for 150SR TWO x day to once a day. I didn’t have a single problem as far as reducing the amount. It’s been several months so no I am going to try & get off it completely. My main problem is anxiety & Wellbutrin makes anxiety worse! I also take 30mg Paxil a day & have for the same amount of time. Without the Paxil I never would have slept at all. I have always been wound up on Wellbutrin.

    It’s an upper like the old time speed that people used to take illegally. It made me irritable, angry, & tightly wound…plus caused major sleep problems. I totally quit drinking recreationally because of the extreme all night vomiting if I would try… now the label says not to drink – it didn’t used to. Anyway I am adding this if you are quitting for financial reasons… the bupropion is a cheap drug!

  • he b gb September 10, 2016, 4:30 am

    Bupropion 150 mg twice a day. Hello everyone. Today is day 6 since I started taking this drug. I was noticing symptoms yesterday and today. Shaking, tremors, being in a fog. I didn’t want to drive even. The reason this was given to me is about 6 months ago my kid brother died of a heart attack, we were very close since our retirements from work.

    Anyway his death hit me like a ton of bricks, just settling his affairs is a ton of work with complications. I would cry when something reminded me of him out of the blue, it wouldn’t last long. I have many hobbies since retiring, didn’t want to do any of them, recently from the stress of this situation my doctor prescribed this for me to give me some get up and go.

    My doctor knows me well, we’re friends and I have been seeing him for 17 years. I go every 2 months to stay on top of my blood pressure. Anyway, I got worried noticing these symptoms coming on and wanted to research about the drug and about getting off this drug. Thanks for all the contributions here, you folks are great. I think I would rather work out my emotional problems by myself instead of being on another drug.

    I take 5 pills for the blood pressure, for about 20 years now. Frankly, I am sick and tired of drugs. The side effects some of you experience seem horrible to me. I am supposed to go back to the doctors in 3 weeks, but I don’t know if I want my body to have 3 more weeks of this drug. So, I will see the doc this week, tell him what I think of this med, tell him I want off it and see what he says.

    Thanks for all your comments, it’s a big wake up call for me. If you folks would like me to report back in with what happens, let me know. We take to many drugs, doctors are to quick to right a script for a drug, that’s my humble opinion. Best of luck to all here. he b gb

    • Arneita October 9, 2016, 2:46 am

      Hi he b gb. Good for you. I decided to get off of then. I posted my story about getting off the medication. I feel so much better and out of that fog.
      Best wishes to you!

  • Mike September 15, 2016, 2:18 am

    On 300 extended for three years. Doc said I could quit cold turkey. Friend said he was in similar situation, and didn’t have major problems quitting cold turkey. Do some/many people quit cold turkey with only minimal side effects? I want to give it a try for a number of reason, but this blog has me seriously reconsidering. Thanks.

    • Mary September 20, 2016, 7:54 pm

      Mike, I was on 300 XL for 4 years & went to 150 about 6 months ago. I stayed on that until a few weeks ago and now am off cold turkey. I have only had a slight bit of fatigue and a few brain zaps. I had also read a lot of people having side effects going off, but I want off of this stuff. Good luck.

  • Ron Jeremy September 16, 2016, 1:56 am

    Hey I’ve been off wellbutrin for 4 or 5 months. I know it can take a while for your body to readjust, but how long does it take for your body to re-up your norepinephrine and not be deficient? I went off cold turkey and am experiencing symptoms of epinephrine deficiency like muscle loss and fatigue. It has gotten better though, but still not normal.

  • Susan Jefferson September 16, 2016, 7:10 pm

    I took Wellbutrin for 11 years. The dosage was increased to 300 mgs after taking it for a couple of years. I had just renewed my prescription in May. The next month (June) I felt fine and decided to stop cold turkey. I didn’t have any withdrawal issues and felt fine. A year later (June) my depression returned and I was stressed and couldn’t sleep.

    I started taking 300 mg of Wellbutrin a day and I felt better for almost three months. Three months later I went to see my new psychiatrist because I started feeling stressed and couldn’t sleep. He prescribed Trazodone 1/2 of 100 mg to take at bedtime. He told me to keep taking Wellbutrin because it takes a while to work.

    He told me to come back in 30 days to see how I was doing. The first time I took it, it only took a few days to work. Does it take four months to work because I had quit taking it for a year after taking it for 11 years?

  • Nancy Baney October 4, 2016, 5:30 pm

    I am planning to taper off of Wellbutrin after many years. I cannot take the generic and insurance will not cover the cost of Wellbutrin XL 300 mg. I was recently diagnosed with Hashimoto thyroiditis which is an autoimmune disease. I am very low in B12 and other deficiencies as well. I am reading and learning to sort through much info.

    I believe my depression and anxiety will be helped by healing my body through diet, supplements, exercise, talk therapy, my trust in God’s faithfulness, and also thyroid hormone. So much to learn but I am hopeful. Glad I finally saw an endocrinologist. So hope this might be helpful to someone.

  • Sarah l October 5, 2016, 12:57 am

    I really had high hopes for Wellbutrin considering it is said to have low side effects, and I’ve never reacted bad to antidepressants before. It is true, however, that everyone is different, seeing that my body did NOT like this drug. I started at 100mg a day and only got up to 150mg, but even at 100mg, I experienced horrible anxiety, confusion, short term memory loss, anger, and restlessness.

    I also gained 12 lbs in 5 weeks. I craved carbs like never before, and couldn’t stop eating. I went roughly from a size 4/6 to 6/8. The brain fog was so bad, I remember losing my keys 3 times while maybe within a 15 minute period, as I was just trying to get out the front door to head to school. I couldn’t focus on anything for the life of me, or else I got extremely frustrated and irritable, and had to drop my college classes for a semester.

    I was on it maybe 4 months, the final month I tapered and went down to 100mg every other day and then just quit. Withdrawals have given me a lot of relief. In fact, 2 days off entirely, and I woke up feeling a lot like myself again, however, I’m having horrible pain and swelling in my hands and joints. I feel like it’s arthritis, except I’m too young to be riddled with arthritis, but my body may just be reacting to the detoxing.

    Now I’m really tired, too, which I’m ok with it since I get to sleep thrift the joint pain. I just thought I’d share this as I didn’t know initially, that my symptoms were side effects from being on the drug. I haven’t heard of anyone having joint pain from withdrawal, but it’s too coincidental for it to have any other cause. It started literally 2 days after going completely off, and got worse around day #7 and it hasn’t lessened except maybe just a smidgen.

    Anyway, there’s my experience with it. I wouldn’t let it stop you from at least trying it since it does have a high rate of effectiveness for many things. Odds are you’ll feel great, and you’ll probably experience weight loss. I know a number of ppl who are loving the drug. My body is just misbehaving… :)

  • Arneita October 9, 2016, 2:40 am

    Wow. I read most of the comments and I’m not going through any of those symptoms while weaning myself off. I’ve been on this medication for about 6 yrs. Don’t subscribe it because I expressed going through depression and wanting to stop smoking. I stopped smoking, loss some weight, etc. But I made lifestyle changes with better healthier eating, exercise, spiritual relationship made the difference.

    I kept telling my Dr I wanted to get off the medication but she kept saying I might as well stay on them for ever if I want to?!! That’s a bunch of crap. That’s when I made up my mind to get healthier, physically, mentally and spiritually. I started weaning myself from 300mg everyday then to every other day for a couple of weeks. After that, down to 150mg every day after a couple weeks every other day.

    I will complete the process for about 2 more weeks then I’m done. I feel great, sleep better, feel alert at work, etc. Get your bodies back on track. There’s others ways to handle things besides popping pills.

  • Nathalie F October 23, 2016, 12:19 am

    I have been taking Citalopram for years at 40mg per day. Nine months ago, my doctor added Bupropion XL 150mg to my regime… We then decided to take me off Citalopram slowly. I took 30 mg for two weeks, then 20mg for two weeks, then 10mg for two weeks and came off citalopram completely 5 weeks ago. had severe withdrawal symptoms for the first weeks I was completely off citalopram, the it seemed to be better but I had bronchitis and had to take antibiotics for that.

    Since I have finished taking the antibiotics and the bronchitis has resolved 6 days ago, I have been feeling like I am having withdrawal symptoms again: headaches, feeling nauseous all day, even vomited a few times three days ago, and finding it hard to function at all, really tired, but I have also noticed dry mouth and weird taste in my mouth, especially at night and early in the morning. Now I just don’t know anymore if this is withdrawal symptoms from the Citalopram still, or side effects from the Bupropion I am taking, or both even…

    Now I just wish I could get off bupropion too… My doc had told me this one wasn’t addictive… your site suggests the contrary… what’s the point in going from one to another? I am feeling so down…

  • Gloria October 27, 2016, 2:16 am

    I had no choice but to stop taking Wellbutrin 300 mg XL cold turkey. My doctors office refused to refill it. In order to have it refilled the doctor office wants full payment up front. My ins deductible is 10 grand. I can’t afford to go see him. I have been on the medication for three years. I was told the reason I was on it is because I have manic depression and borderline bipolar. At this point I don’t know what to do.

  • Judi F November 3, 2016, 8:24 pm

    11/3/16. Hi. I’m Judi F. When I am on Wellbutrin, I have a tendency to be more agitated. My tongue has had nerve damage for almost 30 years ago, when a dentist, Not a surgeon, traumatically removed a wisdom tooth. I was having a hard time deciding whether to get off of the Wellbutrin, because I absentmindedly chew my numb tongue almost constantly. I also jitter a lot with my tapping feet and my shaking knees.

    I have gone cold turkey off of 100 mg time released for four days. I have a lot of joint pain and muscle pain, headaches and lethargy, but I also have been throwing up with a 102° temperature, so I think I had the flu at the same time. The fever is gone, but the joint pain, headaches and nausea are still there. I really want to stay the course and stay off of this medication. It means a lot to me to kick this one.

    Thank you for your help and any suggestions, although I will follow what you have already suggested in your notes. I have told one daughter, but will tell the rest of my family so they can support me in this. They’re good people. Thank you for being so thorough! Judi

  • Laura Zimmerman November 15, 2016, 5:30 pm

    Thank you so much for this information. I was taking a combination of Wellbutrin and Prozac for several years and recently got off the Prozac with pretty good results. I then started tapering off the Wellbutrin (150 mg/day, XL) and have noted agitation, aching in my joints, muscle pain, depression, and cravings like I haven’t had for a long time.

    I was starting to think that I’m just doomed to taking WB for the rest of my life–remember the commercial for an antidepressant med that said “depression hurts”? I thought the pain I was feeling, along with the other symptoms, was my depression coming roaring back. I now feel like I’m on the right track and that I should absolutely continue tapering off. Thank you!

  • Karen December 1, 2016, 2:48 pm

    I went cold turkey off of wellbutrin XL SR last January. I was on this drug for over 30 years. It has now been almost one year that I have been off it. I am still experiencing anger, anxiety, and disassociation, mostly in that order. I am so tired of being angry all the time, I can’t even sleep because of all the things going on in my head rehashing them over and over. Will this ever stop? Or did I just take it too long and my brain can never recover? I really don’t know what to do. Please offer some advice.

  • Hawley December 3, 2016, 12:56 pm

    I have been on anti-depression drugs for 50 years for bi-polar. I just retired as a lawyer and figured now was the time to get off. I was doing 400 mg wellbutrin, 40 celexa and 200 lamictal. It has been 5 months and I am 50% . Wow, this is a trip. Had plans to go out today, but felt like a weighed a ton (I do not). So this is going to be a long trip. Good luck to everyone trying to get off meds.

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